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首页> 外文期刊>Parasitology >Apicomplexans pulling the strings: manipulation of the host cell cytoskeleton dynamics
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Apicomplexans pulling the strings: manipulation of the host cell cytoskeleton dynamics

机译：蚜虫拉线：操纵宿主细胞的细胞骨架动力学

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摘要

Invasive stages of apicomplexan parasites require a host cell to survive, proliferate and advance to the next life cycle stage. Once invasion is achieved, apicomplexans interact closely with the host cell cytoskeleton, but in many cases the different species have evolved distinct mechanisms and pathways to modulate the structural organization of cytoskeletal filaments. The host cell cytoskeleton is a complex network, largely, but not exclusively, composed of microtubules, actin microfilaments and intermediate filaments, all of which are modulated by associated proteins, and it is involved in diverse functions including maintenance of cell morphology and mechanical support, migration, signal transduction, nutrient uptake, membrane and organelle trafficking and cell division. The ability of apicomplexans to modulate the cytoskeleton to their own advantage is clearly beneficial. We here review different aspects of the interactions of apicomplexans with the three main cytoskeletal filament types, provide information on the currently known parasite effector proteins and respective host cell targets involved, and how these interactions modulate the host cell physiology. Some of these findings could provide novel targets that could be exploited for the development of preventive and/or therapeutic strategies.
机译：apicomplexan寄生虫的侵入阶段需要宿主细胞生存，增殖并前进到下一个生命周期阶段。一旦入侵完成，apicomplexans与宿主细胞的细胞骨架紧密相互作用，但在许多情况下，不同物种已经进化出不同的机制和途径来调节细胞骨架细丝的结构组织。宿主细胞的骨架是一个复杂的网络，主要但并非唯一地由微管，肌动蛋白微丝和中间丝组成，它们均由相关蛋白调节，并且涉及多种功能，包括维持细胞形态和机械支持，迁移，信号传导，养分吸收，膜和细胞器运输以及细胞分裂。 apicomplexans调节细胞骨架使其自身优势的能力显然是有益的。我们在这里审查了apicomplexans与三种主要的细胞骨架丝类型相互作用的不同方面，提供了有关当前已知的寄生虫效应蛋白和所涉及的宿主细胞靶标的信息，以及这些相互作用如何调节宿主细胞的生理学。这些发现中的一些可以提供可用于开发预防和/或治疗策略的新颖靶标。

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