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首页> 外文期刊>Parasitology >Alternative energy production pathways in Taenia crassiceps cysticerci in vitro exposed to a benzimidazole derivative (RCB20)
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Alternative energy production pathways in Taenia crassiceps cysticerci in vitro exposed to a benzimidazole derivative (RCB20)

机译：暴露于苯并咪唑衍生物（RCB20）的牛带en虫的体外替代能源生产途径

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摘要

Biochemical studies of benzimidazole derivatives are important to determine their mode of action and activity against parasites. The lack of antihelminthic alternatives to treat parasitic infections and albendazole resistance cases make the search for new antiparasitary drugs of utmost importance. The 6-chloro-5-(1-naphthyloxy)-2-(trifluoromethyl)-1H-benzimidazole (RCB20) is a benzimidazole derivative with promising effect. This study evaluated the effect of different concentrations of RCB20 in the alternative energetic pathway of in vitro Taenia crassiceps cysticerci. The parasites were in vitro exposed to 6.5 and 13 mu M of RCB20 and albendazole sulfoxide (ABZSO). The quantification of acetate, acetoacetate, beta-hydroxybutyrate, fumarate and propionate was performed by high-performance liquid chromatography. The quantification of urea, creatinine and total proteins was performed by spectrophotometry. The increase in beta-hydroxybutyrate reflects the enhancement of the fatty acid oxidation in the treated groups. Volatile fatty acids secretion, acetate and propionate, was increased in the treated groups. The secretion mechanisms of the treated parasites were impaired due to organic acids increased concentrations in the cysticerci. It is possible to conclude that the metabolic effect on alternative energetic pathways is slightly increased in the parasites treated with RCB20 than the ones treated with ABZSO.
机译：苯并咪唑衍生物的生化研究对于确定其对寄生虫的作用方式和活性至关重要。缺乏用于治疗寄生虫感染和阿苯达唑耐药病例的抗蠕虫药替代品，使得寻找新的抗寄生虫药物极为重要。 6-氯-5-（1-萘氧基）-2-（三氟甲基）-1H-苯并咪唑（RCB20）是苯并咪唑衍生物，具有良好的作用。这项研究评估了不同浓度的RCB20在体外猪Ta虫Ta虫能量途径中的作用。将这些寄生虫体外暴露于6.5和13μM的RCB20和阿苯达唑亚砜（ABZSO）中。通过高效液相色谱对乙酸盐，乙酰乙酸盐，β-羟基丁酸盐，富马酸盐和丙酸盐进行定量。尿素，肌酐和总蛋白的定量通过分光光度法进行。 β-羟基丁酸酯的增加反映了处理组中脂肪酸氧化的增强。在治疗组中，挥发性脂肪酸的分泌，乙酸盐和丙酸盐增加。由于有机酸增加了囊尾were中的浓度，因此治疗的寄生虫的分泌机制受损。可以得出结论，与用ABZSO处理的寄生虫相比，使用RCB20处理的寄生虫对替代性能量途径的代谢作用略有增加。

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