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首页> 外文期刊>Parasitology >Evolutionary history of Trypanosoma cruzi according to antigen genes.
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Evolutionary history of Trypanosoma cruzi according to antigen genes.

机译：根据抗原基因的克氏锥虫的进化史。

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摘要

Trypanosoma cruzi, the agent of Chagas disease is associated with a very high clinical and epidemiological pleomorphism. This might be better understood through studies on the evolutionary history of the parasite. We explored here the value of antigen genes for the understanding of the evolution within T. cruzi. We selected 11 genes and 12 loci associated with different functions and considered to be involved in host-parasite interaction (cell adhesion, infection, molecular mimicry). The polymorphism of the respective genes in a sample representative of the diversity of T. cruzi was screened by PCR-RFLP and evolutionary relationships were inferred by phenetic analysis. Our results support the classification of T. cruzi in 2 major lineages and 6 discrete typing units (DTUs). The topology of the PCR-RFLP tree was the one that better fitted with the epidemiological features of the different DTUs: (i) lineage I, being encountered in sylvatic as well as domestic transmission cycles, (ii) IIa/c being associated with a sylvatic transmission cycle and (iii) IIb/d/e being associated with a domestic transmission cycle. Our study also supported the hypothesis that the evolutionary history of T. cruzi has been shaped by a series of hybridization events in the framework of a predominant clonal evolution pattern.
机译：恰加斯氏锥虫，恰加斯氏病的病因，与非常高的临床和流行病学多态性有关。通过研究寄生虫的进化史可能会更好地理解这一点。我们在这里探索了抗原基因对于了解克鲁氏锥虫内部进化的价值。我们选择了11个基因和12个与不同功能相关的基因座，并认为它们参与了宿主-寄生虫的相互作用（细胞粘附，感染，分子模拟）。通过PCR-RFLP筛选出代表克氏锥虫多样性的样品中各个基因的多态性，并通过物候分析推断进化关系。我们的结果支持在2个主要谱系和6个离散打字单位（DTU）中对克鲁维酵母的分类。 PCR-RFLP树的拓扑结构更适合于不同DTU的流行病学特征：（i）世系以及家庭传播周期中遇到的谱系I，（ii）IIa / c与sylvatic传播周期，以及（iii）IIb / d / e与国内传播周期有关。我们的研究还支持这样的假说，即在主要克隆进化模式的框架内，一系列杂种事件影响了克鲁氏锥虫的进化历史。

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