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首页> 外文期刊>Parasitology >Were class C iron-containing superoxide dismutases of trypanosomatid parasites initially imported into a complex plastid? A hypothesis based on analyses of their N-terminal targeting signals.
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Were class C iron-containing superoxide dismutases of trypanosomatid parasites initially imported into a complex plastid? A hypothesis based on analyses of their N-terminal targeting signals.

机译：锥虫原虫的C类含铁超氧化物歧化酶最初是否已导入复杂的质体中？一种基于其N端靶向信号分析的假设。

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摘要

Trypanosomatid parasites possess 2 distinct iron-containing superoxide dismutases (Fe-SODs) designated SODA and SODC, both of which are targeted to their mitochondria. In contrast to SODAs that carry typical mitochondrial transit peptides, SODCs have highly unusual mitochondrial targeting signals. Our analyses clearly show that these pre-sequences are bipartite possessing a signal peptide-like domain followed by a transit peptide-like domain. Consequently, they resemble N-terminal extensions of proteins targeted to multi-membrane plastids, suggesting that trypanosomatids once contained a eukaryotic alga-derived plastid. Further support for this hypothesis comes from striking similarities in length, hydropathy profile, and amino acid composition of SODC pre-sequences to those of Euglena and dinoflagellate plastid proteins. To account for these data, we propose that the Trypanosomatidae initially possessed a gene encoding a mitochondrial Fe-SOD with a classical mitochondrial transit peptide. Before or after plastid acquisition, a gene duplication event gave rise to SODA and SODC. In a subsequent evolutionary step a signal peptide was linked to SODC, enabling its import into the plastid. When the trypanosomatid plastid subsequently was lost, natural selection favoured adaptation of the SODC N-terminal signal as a mitochondrial transit peptide and re-targeting to the mitochondrion.
机译：锥虫寄生虫具有2种不同的含铁超氧化物歧化酶（Fe-SOD），分别称为SODA和SODC，两者均针对其线粒体。与携带典型的线粒体转运肽的SODA相比，SODC具有极不寻常的线粒体靶向信号。我们的分析清楚地表明，这些前序列是二分体，具有信号肽样结构域，然后是转运肽样结构域。因此，它们类似于针对多膜质体的蛋白质的N末端延伸，这表明锥虫体曾经含有真核藻类质体。该假说的进一步支持来自于长度，亲水性分布以及SODC序列与裸藻和双鞭毛质体蛋白的相似性，以及惊人的相似性。为了解释这些数据，我们提出锥虫科最初拥有编码具有经典线粒体转运肽的线粒体Fe-SOD的基因。在质体获取之前或之后，基因复制事件产生了SODA和SODC。在随后的进化步骤中，将信号肽连接到SODC，使其能够导入质体。当锥虫体质体随后丢失时，自然选择有利于SODC N端信号作为线粒体转运肽的适应并重新靶向线粒体。

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