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首页> 外文期刊>Parasitology >The effect of single dose versus two doses of praziquantel on Schistosoma haematobium infection and pathology among school-aged children in Mali.
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The effect of single dose versus two doses of praziquantel on Schistosoma haematobium infection and pathology among school-aged children in Mali.

机译：在马里学龄儿童中，单剂量和两次剂量的吡喹酮对血吸虫血红蛋白感染和病理的影响。

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摘要

The aim of this study was to assess the effect of two doses of 40 mg/kg praziquantel with 2 weeks interval versus a standard single dose of 40 mg/kg on cure rates, egg reduction, intensity of infection, and micro-haematuria in Schistosoma haematobium infections. A randomised controlled intervention study was carried out among school-aged children in two different endemic settings with follow-up at 3, 6 and 18 months following drug administration. Differences in cure rates between the two treatment regimens were not significant. However, in high transmission areas, the double treatment regimen was more effective in egg reduction than single treatment regimen and the difference in egg reduction between the two treatments was significant at 3 months (P<0.005), 6 months (P<0.0001) and 18 months (P<0.003) after treatment. There was a significant difference in the effect of the two treatments on prevalence of micro-haematuria at 18-month follow-up in both Koulikoro (P<0.001) and Selingue (P<0.003). The study shows that although no significant difference could be observed in the overall cure-rates between the two treatment regimens, the effect of double treatment was a significant reduction in infection intensity as well as micro-haematuria which may have a great impact in reducing subtle morbidity.
机译：这项研究的目的是评估两次剂量为40 mg / kg吡喹酮与间隔2周的标准单次剂量40 mg / kg相比，对血吸虫病治愈率，减蛋率，感染强度和微血尿的影响血友病感染。在两个不同的流行地方，对学龄儿童进行了一项随机对照干预研究，并在服药后3、6和18个月进行了随访。两种治疗方案的治愈率差异不显着。然而，在高传播地区，双重治疗方案在减蛋方面比单一治疗方案更有效，并且两种治疗之间的减蛋差异在3个月（P <0.005），6个月（P <0.0001）和3个月时显着。治疗后18个月（P <0.003）。在Koulikoro（P <0.001）和Selingue（P <0.003）中，两种治疗对18个月微血尿的患病率都有显着差异。研究表明，尽管两种治疗方案的总治愈率没有显着差异，但是双重治疗的效果是显着降低了感染强度以及微血尿，这可能对减少细微变化有很大影响。发病率。

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