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首页> 外文期刊>Parasitology >Aggravation of pathogenesis mediated by ochratoxin A in mice infected with Trypanosoma brucei rhodesiense.
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Aggravation of pathogenesis mediated by ochratoxin A in mice infected with Trypanosoma brucei rhodesiense.

机译：感染了布氏锥虫罗氏锥虫的小鼠中曲霉毒素A介导的发病机理加重。

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摘要

Mice fed 1.5 mg ochratoxin A (OTA) per kg body weight and infected with Trypanosoma brucei rhodesiense were compared with trypanosome-infected placebo-fed and uninfected OTA-fed controls. Uninfected OTA-fed mice showed fever, lethargy, facial and eyelid oedemas, mild hepatitis and nephritis, and high survival. Infected placebo-fed controls had mean pre-patent period (PPP) of 3.26 days, lethargy, dyspnoea, fever, facial and scrotal oedema, survival of 33-65 days, reduced red cell counts (RCC: 10.96-6.87x106 cells/microl of blood), packed cell volume (PCV: 43.19-26.36%), haemoglobin levels (Hb: 13.37-7.92 g/dL) and mean corpuscular volume (MCV) of 37.96-41.31 fL, hepatosplenomegaly, generalized oedemas, heart congestion, hepatitis and nephritis. Compared to infected placebo-fed controls, infected OTA-fed mice had significantly (P<0.05) shorter mean PPP (2.58 days), reduced survival (6-47 days), more pronounced fever and dyspnoea. The latter had significantly (P<0.05) reduced RCC (10.74-4.56x106 cells/microl of blood), PCV (43.90-20.78%), Hb (13.06-5.74 g/dL), increased MCV (39.10-43.97 fL), severe generalized oedemas, haemorrhages, congestion, hepatic haemosiderosis, hepatitis, nephritis, endocarditis, pericarditis and exclusively, splenic macrophage and giant cell hyperplasia, expanded red pulp and splenic erythrophagocytosis. It was concluded that OTA aggravated the pathogenesis of T. b. rhodesiense infection in mice, and should therefore be taken into consideration during trypanosomosis control programmes.
机译：将每公斤体重喂饲1.5 mg ra曲霉毒素A（OTA）并感染了布氏锥虫的小鼠与锥虫感染的安慰剂喂养和未感染的OTA喂养的对照组进行比较。未感染OTA的小鼠表现出发烧，嗜睡，面部和眼睑水肿，轻度肝炎和肾炎，并且存活率高。感染安慰剂喂养的对照组的平均专利前期（PPP）为3.26天，嗜睡，呼吸困难，发烧，面部和阴囊水肿，生存期为33-65天，红细胞计数降低（RCC：10.96-6.87x106细胞/微升血液），细胞堆积体积（PCV：43.19-26.36％），血红蛋白水平（Hb：13.37-7.92 g / dL）和平均红细胞体积（MCV）为37.96-41.31 fL，肝脾肿大，全身性水肿，心脏充血，肝炎和肾炎。与感染安慰剂喂养的对照组相比，感染OTA喂养的小鼠的平均PPP显着缩短（P <0.05）（2.58天），生存期缩短（6-47天），发烧和呼吸困难更加明显。后者的RCC（10.74-4.56x106细胞/微升血液），PCV（43.90-20.78％），Hb（13.06-5.74 g / dL）显着（P <0.05），MCV（39.10-43.97 fL），严重的全身性水肿，出血，充血，肝性铁血黄素沉着症，肝炎，肾炎，心内膜炎，心包炎以及仅脾脏巨噬细胞和巨细胞增生，红髓扩大和脾红细胞增多症。结论是OTA加剧了T.b的发病机理。在小鼠中感染了罗氏菌，因此在锥虫病控制计划中应将其考虑在内。

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