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首页> 外文期刊>Parasitology >The influence of transmission season on parasitological cure rates and intensity of infection after praziquantel treatment of Schistosoma haematobium-infected schoolchildren in Mozambique.
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The influence of transmission season on parasitological cure rates and intensity of infection after praziquantel treatment of Schistosoma haematobium-infected schoolchildren in Mozambique.

机译：在莫桑比克吡喹酮治疗血吸虫血吸虫感染的学童后，传播季节对寄生虫治愈率和感染强度的影响。

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摘要

Schistosoma haematobium is refractory to praziquantel (PZQ) during the prepatent period of infection. A hypothesis based on this observation is that in areas where S. haematobium transmission is seasonal, the outcome of chemotherapy depends on the timing of the treatment relative to the annual transmission pattern. To examine this hypothesis, a study was carried out in southern Mozambique. Following demonstration of seasonal transmission, PZQ was administered separately to two cohorts of S. haematobium-infected schoolchildren in (1) the high and (2) the low transmission seasons and followed up after two months when levels of infection and intensities were measured. The prevalence of infection decreased from 54.2% and 51.7% in cohorts 1 and 2 to 30.3% and 1.8%, respectively. The geometric mean intensity of infection decreased from 23.3 eggs/10 ml of urine at baseline to 15.6 eggs/10 ml of urine in cohort 1 (treated during high transmission season), and from 23.5 eggs/10 ml urine to 7.3 eggs/10 ml of urine in cohort 2 (treated during low transmission season). The observed cure rates in cohorts 1 and 2 were 69.7% and 98.2%, respectively. Differences in infection between the cohorts in terms of cure rate and level of infection two months post-treatment were statistically significant and indicate that in areas with a seasonal transmission pattern, the effect of PZQ can be enhanced if treatment takes place during the low transmission season. We conclude that appropriately timed PZQ administration will increase the impact of schistosomiasis control programmes.
机译：血吸虫血吸虫在感染前期对吡喹酮（PZQ）具有耐药性。基于该观察结果的假设是，在血生链球菌传播为季节性的地区，化学疗法的结果取决于相对于年度传播方式的治疗时机。为了检验这一假设，在莫桑比克南部进行了一项研究。在证实季节性传播后，分别在（1）高传播季节和（2）低传播季节向两个队列感染链球菌的学童分别施用PZQ，并在两个月后进行感染水平和强度的测量。感染发生率从队列1和队列2的54.2％和51.7％分别降至30.3％和1.8％。感染的几何平均强度从基线时的23.3卵/ 10 ml尿降至队列1中的15.6卵/ 10 ml尿（在高传播季节进行处理），从23.5卵/ 10 ml尿降至7.3卵/ 10 ml队列2中的尿液（在低传播季节进行了处理）。在队列1和队列2中观察到的治愈率分别为69.7％和98.2％。在治疗后两个月，队列之间在治愈率和感染水平方面的感染差异具有统计学意义，表明在季节性传播模式的地区，如果在低传播季节进行治疗，PZQ的效果会增强。 。我们得出结论，适当定时的PZQ管理将增加血吸虫病控制计划的影响。

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