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首页> 外文期刊>Parasitology >Cyclin-dependent kinase inhibitors block erythrocyte invasion and intraerythrocytic development of Babesia bovis in vitro.
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Cyclin-dependent kinase inhibitors block erythrocyte invasion and intraerythrocytic development of Babesia bovis in vitro.

机译：细胞周期蛋白依赖性激酶抑制剂可在体外阻断牛肝细胞的侵袭和红细胞内发育。

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SUMMARYCyclin-dependent kinases (CDKs) are essential for the regulation of the eukaryotic cell cycle. A number of chemicals, which selectively inhibit the CDK activities, have been synthesized for the development of anti-cancer drugs. This report describes the inhibitory effect of purine derivatives known to be CDK inhibitors on the asexual growth of Babesia bovis. The 4 compounds, roscovitine, purvalanol A, CGP74514A, and CDK2 Inhibitor II, showed significantly suppressive effects on the in vitro growth of B. bovis. Three (roscovitine, purvalanol A, and CDK2 Inhibitor II) showed an inhibitory effect on the early stages of intraerythrocytic development of B. bovis. CGP74514A (CDK1-specific inhibitor) blocked the erythrocyte invasion by merozoites. Our data suggest the chemotherapeutic potential of the CDK inhibitors for babesiosis, and the target molecules of the compounds would participate in the process of successful erythrocyte invasion or intraerythrocytic development of B. bovis.
机译：概述细胞周期蛋白依赖性激酶（CDKs）对于真核细胞周期的调控至关重要。已经合成了许多选择性抑制CDK活性的化学物质以开发抗癌药物。该报告描述了已知为CDK抑制剂的嘌呤衍生物对牛肝菌的无性生长的抑制作用。 roscovitine，嘌呤醇A，CGP74514A和CDK2抑制剂II这4种化合物对牛双歧杆菌的体外生长表现出显着的抑制作用。三种（roscovitine，purvalanol A和CDK2抑制剂II）显示出对牛双歧杆菌红细胞内发育早期的抑制作用。 CGP74514A（CDK1特异性抑制剂）阻止裂殖子入侵红细胞。我们的数据表明CDK抑制剂对杆状杆菌的化学治疗潜力，并且该化合物的目标分子将参与成功的牛红血球侵袭或红细胞内发育的过程。

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