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首页> 外文期刊>Parasitology >The schistosome in the mammalian host: understanding the mechanisms of adaptation.
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The schistosome in the mammalian host: understanding the mechanisms of adaptation.

机译：哺乳动物宿主中的血吸虫：了解适应机制。

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In this review, we envisage the host environment, not as a hostile one, since the schistosome thrives there, but as one in which the relationship between the two organisms consists of constant communication, through signalling mechanisms involving sense organs, surface glycocalyx, surface membrane and internal organs of the parasite, with host fluids and cells. The surface and secretions of the schistosome egg have very different properties from those of other parasite stages, but adapted for the dispersal of the eggs and for the preservation of host liver function. We draw from studies of mammalian cells and other organisms to indicate how further work might be carried out on the signalling function of the surface glycocalyx, the raft structure of the surface and existence of pores in the surface membrane, the repair of the surface membrane, the role of the membrane structure in ion channel function (including recent work on the actin cytoskeleton and calcium channels) and the possible role of P-glycoproteins in the adaptation of the parasite to its environment. We are speculative in some areas, such as the suggestions that variability in surface properties of schistosomes may relate to the existence of membrane rafts and that parasite communities may exhibit quorum sensing. This speculative approach is adopted with the hope that future work on the whole organisms and their interactions will be encouraged.
机译：在这篇综述中，我们设想宿主环境不是一种有害的环境，因为那里的血吸虫病可以在其中生长，而是作为一种有机体，其中两种生物之间的关系是通过涉及感官器官，表面糖萼，表面膜的信号传导机制不断沟通和寄生虫的内部器官，以及宿主的液体和细胞。血吸虫卵的表面和分泌物具有与其他寄生虫阶段非常不同的特性，但是适合于卵的分散和宿主肝功能的保留。我们从对哺乳动物细胞和其他生物的研究中指出，如何对表面糖萼的信号传导功能，表面的筏结构和表面膜中的孔的存在，表面膜的修复，膜结构在离子通道功能中的作用（包括最近对肌动蛋白细胞骨架和钙通道的研究）以及P-糖蛋白在寄生虫适应环境中的可能作用。我们在某些领域是投机性的，例如关于血吸虫表面特性的变化可能与膜筏的存在以及寄生虫群落可能表现出群体感应有关的建议。采用这种推测性方法是希望鼓励将来在整个生物及其相互作用方面的工作。

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