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首页> 外文期刊>Parasitology >Exploring metabolomic approaches to analyse phospholipid biosynthetic pathways in Plasmodium.
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Exploring metabolomic approaches to analyse phospholipid biosynthetic pathways in Plasmodium.

机译：探索代谢组学方法来分析疟原虫中的磷脂生物合成途径。

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SUMMARYPlasmodium falciparum, the agent responsible for malaria, is an obligate intracellular protozoan parasite. For proliferation, differentiation and survival, it relies on its own protein-encoding genes, as well as its host cells for nutrient sources. Nutrients and subsequent metabolites are required by the parasites to support their high rate of growth and replication, particularly in the intra-erythrocytic stages of the parasite that are responsible for the clinical symptoms of the disease. Advances in mass spectrometry have improved the analysis of endogenous metabolites and enabled a global approach to identify the parasite's metabolites by the so-called metabolomic analyses. This level of analysis complements the genomic, transcriptomic and proteomic data already available and should allow the identification of novel metabolites, original pathways and networks of regulatory interactions within the parasite, and between the parasite and its hosts. The field of metabolomics is just in its infancy in P. falciparum, hence in this review, we concentrate on the available methodologies and their potential applications for deciphering important biochemical processes of the parasite, such as the astonishingly diverse phospholipid biosynthesis pathways. Elucidating the regulation of the biosynthesis of these crucial metabolites could help design of future anti-malarial drugs.
机译：概述恶性疟原虫是引起疟疾的病原，是专性的细胞内原生动物寄生虫。对于增殖，分化和存活，它依赖于自身的蛋白质编码基因以及其宿主细胞作为营养来源。寄生虫需要营养物质和随后的代谢产物来支持其高生长和复制速度，特别是在寄生虫的促红细胞生成阶段，该阶段是造成该疾病的临床症状的原因。质谱技术的进步改善了对内源性代谢物的分析，并通过一种全局方法通过所谓的代谢组学分析来鉴定寄生虫的代谢物。这种分析水平是对已有的基因组，转录组和蛋白质组学数据的补充，应能够鉴定出新的代谢产物，寄生虫内部以及寄生虫及其宿主之间的调控相互作用的原始途径和网络。代谢组学的研究还只是在恶性疟原虫中处于起步阶段，因此，在本综述中，我们集中于可利用的方法及其在破译该寄生虫重要生化过程（例如惊人的多样化磷脂生物合成途径）方面的潜在应用。阐明这些重要代谢产物的生物合成调控可能有助于设计未来的抗疟药。

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