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首页> 外文期刊>Parasitology >The selection of experimental doses and their importance for parasite success in metacercarial infection studies.
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The selection of experimental doses and their importance for parasite success in metacercarial infection studies.

机译：实验剂量的选择及其对meta骨感染研究中寄生虫成功的重要性。

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Experimental studies of parasite transmission are essential for advances in basic and applied parasitology. A survey of the results of published experiments can identify the determinants of both variation among studies in experimental design and of parasite infection success. Here, analyses are conducted on data compiled from a total of 106 metacercarial infection experiments (35 on Echinostomatidae, 37 on Fasciolidae, 34 on other trematodes) obtained from 83 studies. All of these involved experimental oral infection of individual definitive hosts by a single known dose of metacercariae under controlled conditions. Across these studies, the metacercarial dose used (i) was typically about 10 times higher than the average natural dose that could be acquired by feeding on intermediate hosts (for taxa other than Fasciolidae), and (ii) showed a positive relationship with the body mass of the definitive host, although this relationship was only significant for Fasciolidae. Although the chosen dose was rarely justified, the larger the definitive host, the more metacercariae it received. Among Echinostomatidae and Fasciolidae, there was also a significant dose-dependent effect on infection success: the higher the dose used in an experiment, the smaller the proportion of metacercariae recovered from the host. This effect was mitigated by definitive host body mass, with infection success being generally lower in larger definitive hosts. For Echinostomatidae, the taxonomic identity of the definitive host also mattered, with metacercariae achieving higher infection success in mammals than in birds. The present findings suggest that the design of experimental infection studies requires greater consideration if their results are to yield useful biological insights.
机译：寄生虫传播的实验研究对于基础寄生虫和应用寄生虫学的发展至关重要。对已发表实验的结果进行的调查可以确定实验设计研究之间的差异以及寄生虫感染成功的决定因素。在此，对从83项研究中获得的总共106例meta骨感染实验（experiments虫科35例，Fa科37例，其他线虫的34例）收集的数据进行了分析。所有这些都涉及在受控条件下通过单一已知剂量的尾cer虫对单个定型宿主进行的实验性口腔感染。在这些研究中，所用的cer骨骨剂量（i）通常比以中间宿主为食（对于Fasciolidae以外的类群）所获得的平均自然剂量高约10倍，并且（ii）与身体呈正相关最终宿主的质量，尽管这种关系只对凤尾科有重要意义。尽管很少选择所选择的剂量，但确定的宿主越大，其接受的尾aria越多。在棘皮mat科和Fasciolidae中，对感染成功也有显着的剂量依赖性作用：实验中使用的剂量越高，从宿主中回收的meta尾proportion的比例越小。最终的宿主体重减轻了这种影响，在较大的最终宿主中感染成功率通常较低。对于棘皮mat科动物而言，确定宿主的生物分类身份也很重要，在哺乳动物中，meta尾aria的成功感染率要高于鸟类。目前的发现表明，实验感染研究的设计要想获得有用的生物学见解，就需要更多的考虑。

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