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首页> 外文期刊>Parasitology >Association of MMP-2 and MMP-9 with clinical outcome of neurocysticercosis.
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Association of MMP-2 and MMP-9 with clinical outcome of neurocysticercosis.

机译：MMP-2和MMP-9与神经囊虫病的临床结局的关联。

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摘要

Matrix metalloproteinases (MMPs) are the major endopeptidases involved in proteolysis of blood brain barrier (BBB) during central nervous system (CNS) infections. The present study detected serum levels and activities of MMP-2 and MMP-9 in patients with neurocysticercosis (NCC) and their association with symptomatic disease. In total, 68 individuals with NCC (36 symptomatic patients with active seizures and 32 asymptomatic individuals) and 37 healthy controls were enrolled for the study. Serum MMP-2 and MMP-9 levels and their activities were measured by ELISA and gel zymography respectively. Mean serum MMP-2 levels (ng/ml) were higher both in asymptomatic and symptomatic NCC cases compared to healthy controls. However, significantly higher levels of serum MMP-9 (ng/ml) were detected only in symptomatic NCC patients compared to asymptomatic NCC cases and healthy controls. Levels of both MMPs positively correlated with symptomatic NCC. Serum MMP-2 activities were significantly higher in symptomatic and asymptomatic NCC compared to healthy controls whereas serum MMP-9 activity was significantly associated with symptomatic NCC compared to healthy controls and asymptomatic NCC. In conclusion, the elevated level of MMP-9 in serum appears to play an important role in the development of symptoms i.e. active seizures in patients with NCC. However, further studies are needed to elucidate its precise role in disease pathogenesis.
机译：基质金属蛋白酶（MMP）是中枢神经系统（CNS）感染过程中涉及的血脑屏障（BBB）蛋白水解的主要内肽酶。本研究检测了神经囊尾osis病（NCC）患者的血清水平，MMP-2和MMP-9活性及其与症状性疾病的关系。总共纳入了68例NCC患者（36例有症状的癫痫发作患者和32例无症状患者）和37例健康对照者进行研究。分别通过ELISA和凝胶酶谱法测定血清MMP-2和MMP-9水平及其活性。与健康对照组相比，无症状和症状性NCC患者的平均血清MMP-2水平（ng / ml）更高。但是，与无症状的NCC病例和健康对照相比，仅在有症状的NCC患者中检测到明显更高的血清MMP-9（ng / ml）水平。两种MMP的水平与症状性NCC呈正相关。与健康对照组和无症状NCC相比，有症状和无症状NCC的血清MMP-2活性显着较高，而有症状NCC的血清MMP-9活性与有症状的NCC显着相关。总之，血清中MMP-9水平的升高似乎在症状的发展中发挥重要作用，即在NCC患者中积极发作。但是，需要进一步的研究来阐明其在疾病发病机理中的确切作用。

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