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首页> 外文期刊>Parasitology >Spatio-temporal variations and age effect on Toxoplasma gondii seroprevalence in seals from the Canadian Arctic.
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Spatio-temporal variations and age effect on Toxoplasma gondii seroprevalence in seals from the Canadian Arctic.

机译：加拿大北极海豹中弓形虫血清流行的时空变化和年龄影响。

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摘要

Toxoplasmosis is a significant public health threat for Inuit in the Canadian Arctic. This study aimed to investigate arctic seals as a possible food-borne source of infection. Blood samples collected from 828 seals in 7 Canadian Arctic communities from 1999 to 2006 were tested for Toxoplasma gondii antibodies using a direct agglutination test. Polymerase chain reaction (PCR) was used to detect T. gondii DNA in tissues of a subsample of seals. Associations between seal age, sex, species, diet, community and year of capture, and serological test results were investigated by logistic regression. Overall seroprevalence was 10.4% (86/828). All tissues tested were negative by PCR. In ringed seals, seroprevalence was significantly higher in juveniles than in adults (odds ratio=2.44). Overall, seroprevalence varied amongst communities (P=0.0119) and by capture year (P=0.0001). Our study supports the hypothesis that consumption of raw seal meat is a significant source of infection for Inuit. This work raises many questions about the mechanism of transfer of this terrestrial parasite to the marine environment, the preponderance of infection in younger animals and the natural course of infection in seals. Further studies to address these questions are essential to fully understand the health risks for Inuit communities.
机译：弓形虫病是加拿大北极地区因纽特人的重大公共卫生威胁。这项研究旨在调查北极海豹作为可能的食源性感染源。使用直接凝集试验，对1999年至2006年从加拿大7个北极社区的828只海豹收集的血液样本进行了弓形虫抗体的检测。聚合酶链反应（PCR）用于检测海豹亚样本组织中的弓形虫DNA。通过逻辑回归研究海豹的年龄，性别，种类，饮食，群落和捕获年份与血清学检测结果之间的关联。总体血清阳性率为10.4％（86/828）。 PCR检测的所有组织均为阴性。在环斑海豹中，青少年的血清阳性率显着高于成人（优势比= 2.44）。总体而言，各社区之间的血清阳性率不同（P = 0.0119），而捕获年份之间也不同（P = 0.0001）。我们的研究支持以下假设：食用海豹肉是因纽特人的重要感染源。这项工作提出了许多关于这种陆生寄生虫向海洋环境转移的机制，幼小动物感染的优势以及海豹感染的自然过程的许多问题。进一步研究这些问题对于充分了解因纽特人社区的健康风险至关重要。

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