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首页> 外文期刊>Parasitology >Inhibition of gametogenesis by the cestode Ligula intestinalis in roach (Rutilus rutilus) is attenuated under laboratory conditions.
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Inhibition of gametogenesis by the cestode Ligula intestinalis in roach (Rutilus rutilus) is attenuated under laboratory conditions.

机译：在实验室条件下减弱了蟑螂（Rutilus rut​​ilus）的小肠小舌小肠天蛾对配子发生的抑制作用。

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摘要

Reproductive parameters of Ligula intestinalis-infected roach (Rutilus rutilus) which were held under long-tem laboratory conditions with unlimited food supply were investigated. Although uninfected and infected roach showed no difference in condition factor and both groups deposited perivisceral fat, the gonadosomatic-index was significantly lower in infected female and male roach. Quantitative histological analysis revealed that gonad development was retarded upon parasitization in both genders. In contrast to the phenotype described in the field, infected females were able to recruit follicles into secondary growth, but a high percentage of secondary growth follicles underwent atresia. In both genders, the histological data corresponded well with reduced expression of pituitary gonadotropins and lowered plasma concentrations of sex steroids, as revealed by real-time RT-PCR and ELISA, respectively. Furthermore, a reduction of vitellogenin mRNA and modulated expression of sex steroid receptors in the liver was demonstrated. Like in the field, there was a significant adverse impact of L. intestinalis on host reproductive physiology which could not be related to parasite burden. Our results show, for the first time, that maintenance under laboratory conditions can not abolish the deleterious effect of L. intestinalis on gametogenesis in roach, and indicate a specific inhibition of host reproduction by endocrine disruption.
机译：研究了在长期实验室条件下，食物供应无限的条件下，被食蟹小肠感染的蟑螂（Rutilus rut​​ilus）的生殖参数。尽管未感染和感染的蟑螂在条件因素上没有差异，两组均沉积内脏脂肪，但感染的雌性和雄性蟑螂的性腺体指数明显较低。定量的组织学分析显示，两性寄生后性腺发育受到阻碍。与本领域中描述的表型相反，受感染的雌性能够募集卵泡进入次级生长，但是高百分比的次级生长卵泡闭锁。两种性别的组织学数据都与垂体促性腺激素的表达降低和性类固醇的血浆浓度降低相对应，分别通过实时RT-PCR和ELISA揭示。此外，证明了卵黄蛋白原mRNA的减少和肝脏中性类固醇受体的调节表达。像在田间一样，小肠乳酸杆菌对寄主的生殖生理有严重的不利影响，这与寄生虫的负担无关。我们的结果首次表明，在实验室条件下进行的维持不能消除小肠乳酸杆菌对蟑螂配子发生的有害作用，并表明通过内分泌干扰特异性抑制宿主繁殖。

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