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Parasitology thanks the Referees of 2011

机译：寄生虫学感谢2011年的裁判

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We evaluated the pharmacokinetics of clindamycin and the dose of clindamycin phosphate necessary to treat peritonitis after intraperitoneal administration of clindamycin phosphate to patients on continuous ambulatory peritoneal dialysis (CAPD). This was an open-label, prospective, single-dose study conducted at the two levels of institutional clinical care in South Korea. Twelve patients (six men and six women; all older than 25years), mean CAPD duration of 38.2months with various origins without peritonitis, received 600mg clindamycin phosphate mixed with only the first 2-L dialysate (1.5% dextrose). The 1.5%, 1.5%, 2.5% and 1.5% dextrose dialysates were serially exchanged every 6hr. If patients were non-anuric, 24-hr urine samples were also collected. Clindamycin phosphate was incompletely activated to clindamycin in the dialysate. The clindamycin concentration in the dialysate was greater than the effective concentration (5μg/mL) at 6.87μg/mL up to 6hr. So, 600mg clindamycin phosphate per every 6hr dialysate is effective for treatment of peritonitis. It has been reported that the clindamycin concentrations in the dialysate may be higher in CAPD patients with peritonitis. Thus, we can expect that intraperitoneal administration of <600mg clindamycin phosphate per every 6hr dialysate could be maintained over 5μg/mL in patients with peritonitis. The transfer of clindamycin was unidirectional from the dialysate to the plasma.
机译：我们评估了克林霉素的药代动力学和磷酸盐克林霉素的剂量，该剂量在连续非卧床腹膜透析（CAPD）腹膜内给予磷酸盐克林霉素治疗后可治疗腹膜炎。这是在韩国的两个机构临床护理水平上进行的开放性，前瞻性，单剂量研究。 12名患者（6名男性和6名女性;年龄均在25岁以上）平均CAPD持续时间为38.2个月，有多种原因而无腹膜炎，他们接受了600mg磷酸克林霉素和仅含首个2 L透析液（1.5％葡萄糖）的混合。每6小时连续交换1.5％，1.5％，2.5％和1.5％的葡萄糖透析液。如果患者无尿，还收集24小时尿液样本。磷酸克林霉素在透析液中未完全活化为克林霉素。直到6小时，透析液中的克林霉素浓度大于有效浓度（5μg/ mL），为6.87μg/ mL。因此，每6小时透析液使用600mg磷酸克林霉素可有效治疗腹膜炎。据报道，在患有腹膜炎的CAPD患者中，透析液中的克林霉素浓度可能更高。因此，我们可以预期腹膜炎患者每6个小时透析液腹膜内给予<600mg磷酸克林霉素可以维持在5μg/ mL以上。克林霉素是从透析液到血浆的单向转移。

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