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首页> 外文期刊>Parasitology >The kinetics of exsheathment of infective nematode larvae is disturbed in the presence of a tannin-rich plant extract (sainfoin) both in vitro and in vivo.
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The kinetics of exsheathment of infective nematode larvae is disturbed in the presence of a tannin-rich plant extract (sainfoin) both in vitro and in vivo.

机译：在体外和体内，在富含单宁的植物提取物（sainfoin）的存在下，感染性线虫幼虫的排出动力学受到干扰。

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The mode of action of bioactive plants on gastrointestinal nematodes remains obscure. Previous in vitro studies showed that exsheathment was significantly disturbed after contact with tannin-rich extracts. However, the role of important factors (extract concentration, parasite species) has not been assessed and no information is available on the occurrence in vivo. These questions represent the objectives of this study. The model incorporated the parasites Haemonchus contortus and Trichostrongylus colubriformis with sainfoin as the bioactive plant. A set of in vitro assays was performed, measuring the changes observed, after 3 h of contact with increasing concentrations of sainfoin, on the rate of artificial exsheathment. The results indicated that sainfoin extracts interfered with exsheathment in a dose-dependent manner and the process overall was similar for both nematodes. The restoration of control values observed after adding PEG to extracts confirms a major role for tannins. A second study was performed in vivo on rumen-cannulated sheep fed with different proportions of sainfoin in the diet to verify these in vitro results. The consumption of a higher proportion of sainfoin was indeed associated with significant delays in Haemonchus exsheathment. Overall, the results confirmed that interference with the early step of nematode infection might be one of the modes of action that contributes to the anthelmintic properties of tanniniferous plants.
机译：生物活性植物对胃肠线虫的作用方式仍然不清楚。先前的体外研究表明，与富含单宁的提取物接触后，皮鞘的显着干扰。但是，尚未评估重要因素（提取物浓度，寄生虫种类）的作用，也没有关于体内发生情况的信息。这些问题代表了本研究的目的。该模型结合了寄生虫Haemonchus contortus和Trichostrongylus colubriformis，并以sainfoin作为生物活性植物。进行了一组体外测定，测量了在与不断增加的皂素浓度接触3小时后观察到的对人工排泄速率的变化。结果表明，皂素提取物以剂量依赖的方式干扰着鞘，并且两种线虫的整个过程相似。将PEG添加到提取物中后观察到的控制值的恢复证实了单宁的主要作用。对日粮中饲喂不同比例的皂甙的瘤胃羊进行了第二项研究，以验证这些体外结果。食用较高比例的皂素确实确实与Haemonchus出鞘的显着延迟有关。总体而言，结果证实，干扰线虫感染的早期步骤可能是导致单宁植物驱虫特性的一种作用方式。

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