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首页> 外文期刊>Parasitology >The role of the NTPDase enzyme family in parasites: What do we know, and where to from here?
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The role of the NTPDase enzyme family in parasites: What do we know, and where to from here?

机译：NTPDase酶家族在寄生虫中的作用：我们知道什么，从那里到哪里？

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摘要

Nucleoside triphosphate diphosphohydrolases (NTPDases, GDA1-CD39 protein superfamily) play a diverse range of roles in a number of eukaryotic organisms. In humans NTPDases function in regulating the inflammatory and immune responses, control of vascular haemostasis and purine salvage. In yeast NTPDases are thought to function primarily in the Golgi, crucially involved in nucleotide sugar transport into the Golgi apparatus and subsequent protein glycosylation. Although rare in bacteria, in Legionella pneumophila secreted NTPDases function as virulence factors. In the last 2 decades it has become clear that a large number of parasites encode putative NTPDases, and the functions of a number of these have been investigated. In this review, the available evidence for NTPDases in parasites and the role of these NTPDases is summarized and discussed. Furthermore, the processes by which NTPDases could function in pathogenesis, purine salvage, thromboregulation, inflammation and glycoconjugate formation are considered, and the data supporting such putative roles reviewed. Potential future research directions to further clarify the role and importance of NTPDases in parasites are proposed. An attempt is also made to clarify the nomenclature used in the parasite field for the GDA1-CD39 protein superfamily, and a uniform system suggested.
机译：核苷三磷酸二磷酸水解酶（NTPDase，GDA1-CD39蛋白超家族）在许多真核生物中起着各种各样的作用。在人类中，NTPDases调节炎症和免疫反应，控制血管止血和嘌呤挽救。在酵母中，NTPDase被认为主要在高尔基体中发挥功能，与核苷酸糖转运到高尔基体和随后的蛋白质糖基化至关重要。尽管在肺炎军团菌中很少见，但分泌的NTPDases作为毒力因子起作用。在最近的20年中，很明显，大量的寄生虫编码假定的NTPDase，并且已经研究了其中许多的功能。在这篇综述中，归纳并讨论了寄生虫中NTPDase的可用证据以及这些NTPDase的作用。此外，考虑了NTPDases在发病机理，嘌呤挽救，血栓调节，炎症和糖缀合物形成中起作用的过程，并综述了支持这种假定作用的数据。提出了潜在的未来研究方向，以进一步阐明NTPDase在寄生虫中的作用和重要性。还尝试澄清用于GDA1-CD39蛋白超家族的寄生虫领域中的命名法，并提出了一个统一的系统。

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