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The transfer of IgA from mucus to plasma and the implications for diagnosis and control of nematode infections

机译:IgA从粘液到血浆的转移及其对线虫感染的诊断和控制的意义

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SUMMARY Immunoglobulin A (IgA) activity has been associated with reduced growth and fecundity of Teladorsagia circumcincta. IgA is active at the site of infection in the abomasal mucus. However, while IgA activity in abomasal mucus is not easily measured in live animals without invasive methods, IgA activity can be readily detected in the plasma, making it a potentially valuable tool in diagnosis and control. We used a Bayesian statistical analysis to quantify the relationship between mucosal and plasma IgA in sheep deliberately infected with T. circumcincta. The transfer of IgA depends on mucosal IgA activity as well as its interaction with worm number and size; together these account for over 80% of the variation in plasma IgA activity. By quantifying the impact of mucosal IgA and worm number and size on plasma IgA, we provide a tool that can allow more meaningful interpretation of plasma IgA measurements and aid the development of efficient control programmes.
机译:发明内容免疫球蛋白A(IgA)的活性与环行Teladorsagia的生长和繁殖力降低有关。 IgA在原浆中的感染部位具有活性。然而,尽管在没有侵入性方法的情况下,在活体动物中不易测量出浆液中IgA的活性,但血浆中的IgA活性却很容易检测到,使其成为诊断和控制中潜在的有价值的工具。我们使用贝叶斯统计分析来量化故意感染T.circumcincta的绵羊的粘膜与血浆IgA之间的关系。 IgA的转移取决于粘膜IgA活性及其与蠕虫数量和大小的相互作用。这些因素共同构成了血浆IgA活性变化的80%以上。通过量化粘膜IgA和蠕虫的数量和大小对血浆IgA的影响,我们提供了一种工具,可以对血浆IgA测量值进行更有意义的解释,并有助于制定有效的控制程序。

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