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Heat shock protein 90 as a potential drug target against surra

机译：热休克蛋白90作为对抗Surra的潜在药物靶标

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SUMMARY Trypanosomiasis is caused by Trypanosoma species which affect both human and animal populations and pose a major threat to developing countries. The incidence of animal trypanosomiasis is on the rise. Surra is a type of animal trypanosomiasis, caused by Trypanosoma evansi, and has been included in priority list B of significant diseases by the World Organization of Animal Health (OIE). Control of surra has been a challenge due to the lack of effective drugs and vaccines and emergence of resistance towards existing drugs. Our laboratory has previously implicated Heat shock protein 90 (Hsp90) from protozoan parasites as a potential drug target and successfully demonstrated efficacy of an Hsp90 inhibitor in cell culture as well as a pre-clinical mouse model of trypanosomiasis. This article explores the role of Hsp90 in the Trypanosoma life cycle and its potential as a drug target. It appears plausible that the repertoire of Hsp90 inhibitors available in academia and industry may have value for treatment of surra and other animal trypanosomiasis.
机译：发明内容锥虫病是由锥虫病引起的，锥虫病影响人类和动物种群，并对发展中国家构成重大威胁。动物锥虫病的发病率正在上升。 Surra是一种由伊氏锥虫引起的动物锥虫病，已被世界动物卫生组织（OIE）列入重要疾病的优先级清单B。由于缺乏有效的药物和疫苗以及对现有药物产生抗药性，控制surra成为一项挑战。我们的实验室先前曾暗示来自原生动物寄生虫的热休克蛋白90（Hsp90）作为潜在的药物靶标，并成功地证明了Hsp90抑制剂在细胞培养以及锥虫病的临床前小鼠模型中的功效。本文探讨了Hsp90在锥虫的生命周期中的作用及其作为药物靶标的潜力。看来在学术界和工业界可获得的Hsp90抑制剂库可能对治疗surra和其他动物锥虫病具有价值。

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