...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Parasitology >Experimental infection by haemonchus contortus in lambs: Influence of disease on purine levels in serum
【24h】

Experimental infection by haemonchus contortus in lambs: Influence of disease on purine levels in serum

机译：羊肉中弯曲变形杆菌的实验感染：疾病对血清嘌呤水平的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

SUMMARY The aim of this study was to evaluate the purine levels of lambs experimentally infected with Haemonchus contortus. A total of 12 healthy lambs were divided into two groups, composed of 6 animals each: Group A represented the healthy animals (uninfected), while in Group B the animals were infected with 15 000 larvae of H. contortus. Blood was drawn on days 15, 45 and 75 post-infection (PI) in order to perform the purine analysis (ATP, ADP, AMP, adenosine, inosine, hypoxanthine, xanthine and uric acid) by high pressure liquid chromatography (HPLC) in serum. On day 15 PI a significant (P<0·05) increase in the levels of ATP and inosine was observed in the infected animals, unlike the levels of ADP, adenosine, xanthine and uric acid which were reduced. On day 45 PI a significant (P<0·05) increase in the ATP and xanthine levels in infected animals was observed, contrasting with reduced levels of ADP and uric acid. Finally, on day 75 PI an increase occurred in the levels of ATP, adenosine and hypoxanthine in infected lambs, concomitant with a reduction in the levels of ADP and uric acid (P<0·05). These changes in purine levels may influence the inflammatory process and the pathological events.
机译：概述这项研究的目的是评估实验性感染了捻转血矛线虫的羔羊的嘌呤水平。将总共​​12只健康的羔羊分为两组，每组由6只动物组成：A组代表健康动物（未感染），而B组中的动物则感染了15 000只Contortus的幼虫。在感染后第15、45和75天抽取血液，以通过高压液相色谱（HPLC）进行嘌呤分析（ATP，ADP，AMP，腺苷，肌苷，次黄嘌呤，黄嘌呤和尿酸）。血清。在感染后的第15天，感染动物的ATP和肌苷水平显着增加（P <0·05），这与降低的ADP，腺苷，黄嘌呤和尿酸的水平不同。在第45天，观察到感染动物的ATP和黄嘌呤水平显着（P <0·05）升高，而ADP和尿酸水平降低。最后，在第75天，受感染羔羊的ATP，腺苷和次黄嘌呤水平增加，同时ADP和尿酸水平降低（P <0·05）。嘌呤水平的这些变化可能会影响炎症过程和病理事件。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号