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首页> 外文期刊>Parasitology >Towards malaria microscopy at the point-of-contact: an assessment of the diagnostic performance of the Newton Nm1 microscope in Uganda.
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Towards malaria microscopy at the point-of-contact: an assessment of the diagnostic performance of the Newton Nm1 microscope in Uganda.

机译：接触点上的疟疾显微镜：对乌干达Newton Nm1显微镜的诊断性能的评估。

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摘要

Malaria microscopy in sub-Saharan Africa is often restricted by access to light microscopes. To address this gap, a novel portable inverted monocular microscope, the Newton Nm1, was designed and is now commercially available. Its diagnostic performance was assessed in a blinded-slide trial at ×1000 (oil) of Giemsa-stained thick blood films against a conventional microscope as undertaken by four Ugandan Ministry of Health technicians. With the Newton Nm1, diagnostic performance was: sensitivity 93.5% (95% confidence interval (CI) 78.6-99.2%), specificity 100.0% (95% CI 82.4-100.0%), positive predictive value 100.0% (95% CI 88.1-100.0%) and negative predictive value 90.5% (95% CI 69.6-98.8%). Discordance was due to a systematic error underestimating parasitaemia by ~45%; when counting Plasmodium parasites against 200 white blood cells, blood films with low parasitaemia (i.e. <100 μL(-1) of blood) could be overlooked and misclassified. By contrast, specificity was excellent with no false positives encountered. Whilst proven useful, especially in resource-poor environments, it is still unclear how we can ensure the uptake of the Newton Nm1 within sub-Saharan Africa.
机译：撒哈拉以南非洲地区的疟疾显微镜检查经常受到光学显微镜的限制。为了解决这一空白，设计了一种新型的便携式倒置单眼显微镜，即牛顿Nm1，现已在市场上销售。由四名乌干达卫生部技术人员在常规显微镜下对吉姆萨染色的厚血膜进行×1000（油）的盲滑试验，评估了其诊断性能。使用Newton Nm1，诊断性能为：灵敏度93.5％（95％置信区间（CI）78.6-99.2％），特异性100.0％（95％CI 82.4-100.0％），阳性预测值100.0％（95％CI 88.1-） 100.0％）和阴性预测值90.5％（95％CI 69.6-98.8％）。不一致是由于系统错误将寄生虫病低估了约45％;当针对200个白细胞计数疟原虫寄生虫时，低寄生性血症（即血液<100μL（-1））的血膜可能会被忽略和错误分类。相比之下，特异性极佳，没有出现假阳性。虽然证明是有用的，尤其是在资源匮乏的环境中，但仍不清楚我们如何确保在撒哈拉以南非洲地区吸收Newton Nm1。

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