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首页> 外文期刊>Parasitology >Evaluation of portable microscopic devices for the diagnosis of Schistosoma and soil-transmitted helminth infection.
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Evaluation of portable microscopic devices for the diagnosis of Schistosoma and soil-transmitted helminth infection.

机译：便携式显微镜设备用于诊断血吸虫和土壤传播的蠕虫感染的评估。

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The diagnosis of parasitic worm (helminth) infections requires specialized laboratory settings, but most affected individuals reside in locations without access to such facilities. We tested two portable microscopic devices for the diagnosis of helminth infections in a cross-sectional survey in rural C?te d'Ivoire. We examined 164 stool samples under a light microscope and then re-examined with a commercial portable light microscope and an experimental mobile phone microscope for the diagnosis of Schistosoma mansoni and soil-transmitted helminths. Additionally, 180 filtered urine samples were examined by standard microscopy and compared with the portable light microscope for detection of Schistosoma haematobium eggs. Conventional microscopy was considered the diagnostic reference standard. For S. mansoni, S. haematobium and Trichuris trichiura, the portable light microscope showed sensitivities of 84.8%, 78.6% and 81.5%, respectively, and specificities of 85.7%, 91.0% and 93.0%, respectively. For S. mansoni and T. trichiura, we found sensitivities for the mobile phone microscope of 68.2% and 30.8%, respectively, and specificities of 64.3% and 71.0%, respectively. We conclude that the portable light microscope has sufficient diagnostic yield for Schistosoma and T. trichiura infections, while the mobile phone microscope has only modest sensitivity in its current experimental set-up. Development of portable diagnostic technologies that can be used at point-of-sample collection will enhance diagnostic coverage in clinical and epidemiological settings.
机译：诊断寄生虫（蠕虫）感染需要专门的实验室设置，但是大多数受影响的人居住在无法使用此类设施的地方。在科特迪瓦农村地区的一项横断面调查中，我们测试了两种便携式显微镜设备，用于诊断蠕虫感染。我们在光学显微镜下检查了164个粪便样品，然后用商用便携式光学显微镜和实验性移动电话显微镜进行了重新检查，以诊断曼氏血吸虫和土壤传播的蠕虫。另外，通过标准显微镜检查了180个过滤后的尿液样本，并与便携式光学显微镜进行了比较，以检测血吸虫血吸虫卵。常规显微镜被认为是诊断参考标准。对于曼氏葡萄球菌，血红球菌和Trichuris trichiura，便携式光学显微镜的灵敏度分别为84.8％，78.6％和81.5％，特异性分别为85.7％，91.0％和93.0％。对于曼氏链球菌和Trichiura菌，我们发现手机显微镜的敏感性分别为68.2％和30.8％，特异性分别为64.3％和71.0％。我们得出的结论是，便携式光学显微镜对血吸虫和毛支线虫感染具有足够的诊断率，而移动电话显微镜在当前的实验装置中仅具有中等灵敏度。可用于样本点采集的便携式诊断技术的发展将增强临床和流行病学背景下的诊断覆盖率。

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