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首页> 外文期刊>Parasitology >Successful vaccines for naturally occurring protozoal diseases of animals should guide human vaccine research. A review of protozoal vaccines and their designs
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Successful vaccines for naturally occurring protozoal diseases of animals should guide human vaccine research. A review of protozoal vaccines and their designs

机译：用于动物的天然原生动物疾病的成功疫苗应指导人类疫苗研究。原生动物疫苗及其设计综述

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Effective vaccines are available for many protozoal diseases of animals, including vaccines for zoonotic pathogens and for several species of vector-transmitted apicomplexan haemoparasites. In comparison with human diseases, vaccine development for animals has practical advantages such as the ability to perform experiments in the natural host, the option to manufacture some vaccines in vivo, and lower safety requirements. Although it is proper for human vaccines to be held to higher standards, the enduring lack of vaccines for human protozoal diseases is difficult to reconcile with the comparatively immense amount of research funding. Common tactical problems of human protozoal vaccine research include reliance upon adapted rather than natural animal disease models, and an overwhelming emphasis on novel approaches that are usually attempted in replacement of rather than for improvement upon the types of designs used in effective veterinary vaccines. Currently, all effective protozoal vaccines for animals are predicated upon the ability to grow protozoal organisms. Because human protozoal vaccines need to be as effective as animal vaccines, researchers should benefit from a comparison of existing veterinary products and leading experimental vaccine designs. With this in mind, protozoal vaccines are here reviewed.
机译：有效的疫苗可用于许多动物的原生动物疾病，包括人畜共患病病原体和多种媒介传播的apicomplexan血寄生虫的疫苗。与人类疾病相比，用于动物的疫苗开发具有实际优势，例如在天然宿主中进行实验的能力，可以在体内生产某些疫苗的选项以及较低的安全性要求。尽管将人类疫苗保持在更高的标准是适当的，但是人类原虫病疫苗的长期缺乏难以与相对大量的研究经费相提并论。人类原生动物疫苗研究的常见战术问题包括：依靠适应的模型而不是自然的动物疾病模型，以及对新方法的压倒性强调，这些新方法通常试图代替而不是改进有效兽用疫苗中使用的设计类型。当前，所有有效的动物原生动物疫苗都取决于原生动物生物的生长能力。由于人类原生动物疫苗需要与动物疫苗一样有效，因此研究人员应该从现有兽药产品和领先的实验疫苗设计的比较中受益。考虑到这一点，这里对原生动物疫苗进行了综述。

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