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Amodiaquine-Ciprofloxacin: a potential combination therapy against drug resistant malaria

机译：阿莫地喹-环丙沙星：抗药性疟疾的潜在联合疗法

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Emergence of malaria parasites resistant to artemisinin necessitates the need for development of new antimalarial therapies. Ciprofloxacin (CFX) a second generation quinolone antibiotic possesses some antimalarial activities. We investigated the in vivo antimalarial activities of CFX in combination with amodiaquine in mice infected with chloroquine-resistant Plasmodium berghei ANKA. Animals were treated orally with 80 or 160 mg kg(-1) body weight of CFX alone given twice daily or in combination with amodiaquine (AQ) 10 mg kg(-1) body weight. Parasitological activity and survival of the animals were assessed over 21 days. Peak parasitaemia in the untreated control group was 72.51%. Treatment with AQ alone resulted in clearance of parasitaemia by day 4 while treatment with CFX 80 and 160 mg kg(-1) alone suppressed parasitaemia by 13.94-54.64% and 35.6-92.7%, respectively. However, the combination of CFX with AQ significantly enhanced response of infection in the animals to treatment (P < 0.05) resulting in complete resolution of parasitaemia throughout follow up period with CFX 160 mg kg(-1), delayed recrudescence time with CFX 80 mg kg(-1) and significant increase in survival rate of the animals. The results demonstrate beneficial interaction between AQ and CFX which may provide a clinically relevant antimalarial/antibiotic therapeutic option in the management of malaria.
机译：抗青蒿素的疟原虫的出现需要开发新的抗疟疗法。环丙沙星（CFX）是第二代喹诺酮类抗生素，具有一些抗疟活性。我们调查了CFX与阿莫地喹联合在抗氯喹耐药性伯氏疟原虫ANKA感染的小鼠中的体内抗疟活性。每天两次给动物口服80或160 mg kg（-1）体重的CFX，或与10 mg kg（-1）的阿莫地喹（AQ）联合口服。在21天内评估动物的寄生虫活性和存活率。未经治疗的对照组中的寄生虫血症峰值为72.51％。单独使用AQ进行治疗可在第4天清除寄生虫血症，而单独使用CFX 80和160 mg kg（-1）进行治疗可分别将寄生虫血症抑制13.94-54.64％和35.6-92.7％。然而，CFX与AQ的组合显着增强了动物对治疗的感染反应（P <0.05），从而导致在整个随访期间用CFX 160 mg kg（-1）完全消除了寄生虫血症，使用CFX 80 mg延迟了复发时间kg（-1）并显着提高动物的存活率。结果表明，AQ和CFX之间的有益相互作用可以为疟疾的治疗提供临床相关的抗疟疾/抗生素治疗选择。

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