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首页> 外文期刊>Parasitology Research >Assessing the diagnostic accuracy of immunodiagnostic techniques in the diagnosis of schistosomiasis japonica: a meta-analysis.
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Assessing the diagnostic accuracy of immunodiagnostic techniques in the diagnosis of schistosomiasis japonica: a meta-analysis.

机译：评估免疫诊断技术在日本血吸虫病诊断中的诊断准确性：一项荟萃分析。

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Immunodiagnostic tests are commonly used in the diagnosis for schistosomiasis japonica in field situation. Their diagnostic effect, however, has never been evaluated in a systematic way. We set out to review the value of tests including enzyme-linked immunosorbent assay (ELISA) and indirect hemagglutination assay (IHA) in the diagnosis of schistosomiasis japonica. A comprehensive search was conducted in order to identify all possible studies achieving the inclusion criteria. We undertook a meta-analysis of diagnostic ability that compared ELISA with IHA for the diagnosis of schistosomiasis japonica. Original articles were searched in Pubmed, Science Citation Index Expanded, Cochrane Library, Proquest and China National Knowledge Infrastructure. Data extractions were conducted independently by two reviewers. Summary receiver operating characteristic curves were used to summarize overall test performance. Funnel plot was used to analyze publication bias. Finally, 16 studies met inclusion criteria. In all studies combined, the diagnostic odds ratio (DOR) for IHA was 8.689 (95%CI 7.671 to 9.842) and ELISA was 3.691 (95%CI 3.018 to 4.515). The DOR for IHA was better than that for ELISA. IHA demonstrated TPR* = 0.721 and ELISA showed TPR* = 0.633. IHA performance was superior to that of ELISA. Nevertheless, difference of the accuracy between the two methods for diagnosis of schistosomiasis japonica has no statistical significance as shown by the result of Z test. We found that both IHA and ELISA can be used to rule in or rule out the diagnosis.
机译：免疫诊断测试通常用于野外情况下日本血吸虫病的诊断。然而，它们的诊断作用从未得到系统评价。我们着手审查包括酶联免疫吸附测定（ELISA）和间接血细胞凝集测定（IHA）在内的测试在日本血吸虫病诊断中的价值。为了确定所有可能达到纳入标准的研究，进行了全面搜索。我们进行了诊断能力的荟萃分析，将ELISA与IHA进行了日本血吸虫病诊断的比较。在Pubmed，《科学引文索引》，《 Cochrane图书馆》，《 Proquest》和《中国国家知识基础设施》中搜索原始文章。数据提取由两名审阅者独立进行。汇总接收器工作特性曲线用于汇总总体测试性能。漏斗图用于分析发布偏差。最后，有16项研究符合纳入标准。在所有合并的研究中，IHA的诊断比值比（DOR）为8.689（95％CI 7.671至9.842），ELISA为3.691（95％CI 3.018至4.515）。 IHA的DOR优于ELISA。 IHA显示TPR * = 0.721，ELISA显示TPR * = 0.633。 IHA性能优于ELISA。然而，如Z检验的结果所示，两种诊断日本血吸虫病的方法之间的准确性差异没有统计学意义。我们发现，IHA和ELISA均可用于排除或排除诊断。

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