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首页> 外文期刊>Biomaterials >Tissue ingrowth and degradation of two biodegradable porous polymers with different porosities and pore sizes.
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Tissue ingrowth and degradation of two biodegradable porous polymers with different porosities and pore sizes.

机译：两种孔隙率和孔径不同的可生物降解的多孔聚合物的组织向内生长和降解。

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Commonly, spontaneous repair of lesions in the avascular zone of the knee meniscus does not occur. By implanting a porous polymer scaffold in a knee meniscus defect, the lesion is connected with the abundantly vascularized knee capsule and healing can be realized. Ingrowth of fibrovascular tissue and thus healing capacity depended on porosity, pore sizes and compression modulus of the implant. To study the lesion healing potential, two series of porous polyurethanes based on 50/50 epsilon-caprolactone/L-lactide with different porosities and pore sizes were implanted subcutaneously in rats. Also, in vitro degradation of the polymer was evaluated. The porous polymers with the higher porosity, more interconnected macropores, and interconnecting micropores of at least 30 microm showed complete ingrowth of tissue before degradation had started. In implants with the lower macro-porosity and micropores of 10-15 microm degradation of the polymer occurred before ingrowth was completed. Directly after implantation and later during degradation of the polymer, PMN cells infiltrated the implant. In between these phases the foreign body reaction remained restricted to macrophages and giant cells. We can conclude that both foams seemed not suited for implantation in meniscal reconstruction while either full ingrowth of tissue was not realized before polymer degradation started or the compression modulus was too low. Therefore, foams must be developed with a higher compression modulus and more connections with sufficient diameter between the macropores.
机译：通常，不会在膝盖半月板的无血管区域自发修复病变。通过将多孔聚合物支架植入膝盖半月板缺损，病变与血管丰富的膝盖囊相连，可以实现愈合。纤维血管组织的向内生长以及因此的愈合能力取决于植入物的孔隙率，孔径和压缩模量。为了研究病变的愈合潜力，将两种基于不同孔隙率和孔径的50/50ε-己内酯/ L-丙交酯的多孔聚氨酯系列皮下植入大鼠体内。另外，评估了聚合物的体外降解。具有较高孔隙率，更多互连的大孔和至少30微米的互连微孔的多孔聚合物在降解开始之前显示出组织的完全向内生长。在较低的大孔隙率和10-15微米的微孔的植入物中，聚合物在向内生长完成之前发生了降解。直接在植入后以及随后的聚合物降解过程中，PMN细胞会渗透到植入物中。在这些阶段之间，异物反应仍然局限于巨噬细胞和巨细胞。我们可以得出结论，两种泡沫似乎都不适合在半月板重建中植入，而在聚合物降解开始之前或压缩模量太低之前，尚未实现组织的完全向内生长。因此，必须以更高的压缩模量和更多的连接来开发泡沫，并且在大孔之间具有足够的直径。

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