• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Parkinsonism & related disorders >Botulinum neurotoxin treatment improves force regulation in writer's cramp.
【24h】

Botulinum neurotoxin treatment improves force regulation in writer's cramp.

机译：肉毒杆菌神经毒素治疗可改善作家抽筋中的力量调节。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Writer's cramp patients show poor force regulation during handwriting, but also in other experimental tasks requiring fine motor control. Botulinum neurotoxin (BoNT) treatment is clinically effective in a substantial portion of writer's cramp patients, but the full mechanism of action remains enigmatic. BoNT possibly influences α- and γ-motoneurons through chemodenervation not only of extra-, but also intrafusal muscle fibres and might thus influence muscle spindle afferents. Hence, BoNT weakens injected muscles, but may also modulate sensory aspects of force control. Ten patients and 18 controls pressed their index finger on a force sensor tracking two visual targets: The first target consisted of five plateaus with successively higher force levels and alternated with ascending ramps. In the second target condition the same successive plateaus were to be reached by abrupt jumps. The generated force displayed as a time dependant curve. Root mean square of the difference between target and produced force level was calculated for each plateau/ramp/jump. Patients were treated with BoNT at week 4 and measured at baseline, weeks 2, 4, 6 and 8. Disturbed force regulation in patients for the plateaus and the second jump at baseline resolved after BoNT treatment, and the root mean square of force deviation decreased for the ramps. Fine force control was within the 95% confidence interval of the control group after treatment. In conclusion, force regulation was disturbed in patients and improved after BoNT treatment. This is not compatible with a simple muscle weakening and might thus reflect improved sensorimotor integration.
机译：作家的抽筋患者在手写时以及在其他需要精细运动控制的实验任务中显示出较弱的力量调节。肉毒杆菌神经毒素（BoNT）治疗在大部分作家抽筋患者中临床有效，但完整的作用机制仍然是个谜。 BoNT可能不仅通过融合神经外神经纤维，而且通过融合神经内纤维的化学神经支配影响α-和γ-运动神经元，从而可能影响纺锤体传入神经。因此，BoNT削弱了注入的肌肉，但也可能调节力控制的感觉方面。十名患者和18位控制者将食指压在跟踪两个视觉目标的力传感器上：第一个目标由五个平台组成，这些平台依次具有更高的力量水平，并交替上升。在第二目标条件下，突然跳跃将达到相同的连续平稳期。生成的力显示为时间依赖性曲线。针对每个平稳段/斜坡/跳跃计算目标力和产生力水平之间的差的均方根。在第4周对患者进行BoNT治疗，并在基线，第2、4、6和8周进行了测量。BoNT治疗后高原患者的扰动力调节和基线的第二次跳动得以解决，并且力偏差的均方根减小坡道。治疗后精细力控制在对照组的95％置信区间内。总之，BoNT治疗后患者的力量调节受到干扰并得到改善。这与简单的肌肉衰弱不兼容，因此可能反映出感觉运动整合的改善。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号