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首页> 外文期刊>Swiss medical weekly: official journal of the Swiss Society of Infectious Diseases, the Swiss Society of Internal Medicine, the Swiss Society of Pneumology >Drug-eluting coronary stents in clinical practice: lessons from the ?BAsel Stent Kosten-Effektivitats Trials? (BASKET) A review of the BASKET trials
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Drug-eluting coronary stents in clinical practice: lessons from the ?BAsel Stent Kosten-Effektivitats Trials? (BASKET) A review of the BASKET trials

机译：临床实践中的药物洗脱冠状动脉支架：来自“ BAsel Stent Kosten-Effektivitats试验”的课程？ （篮球）对篮球试验的回顾

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In this review of the BAsel Stent Kosten-Effektivitats Trial (BASKET) the trials and their impact on coronary stenting practice were examined, basing the clinical questions of each study on the findings of the previous study. Are the new drug-eluting stents (DES) cost-effective compared to standard bare-metal stents (BMS) if used in all patients? No. Are there specific subgroups of patients with a particular benefit? Yes. A "targeted stent use" was proposed for daily practice. What is the long-term safety of DES? Unexpected safety problems were observed. Was this a chance finding? No. However, with improved stenting techniques, newer stents and intensified antiplatelet regimens late problems were minimised as shown in the BASKET-PRO-spective Validation Examination (BASKET-PROVE). Further stent developments? Wait and see! - Many additional questions were raised and answered or are still under investigation. Obviously, answers were not always simple and needed a closer look and this is discussed. The BASKET trials proceeded not only from one question to the other, but also in size and methodology. From the restricted single-centre "local" BASKET study to multicentre international long-term trials, all prospective, randomized and investigator-driven. Their relevance was acknowledged by publications in major medical journals as well as by their impact on US and European practice guidelines and on DES research. These aspects are summarised in the present review, highlighting lessons learned from each study and commenting on the possibilities and difficulties of performing such clinical research in Switzerland.
机译：在对BAsel Stent Kosten-Effektivitats试验（BASKET）的审查中，根据每个研究的临床问题，根据先前研究的结果，对试验及其对冠状动脉支架置入术的影响进行了检查。如果在所有患者中使用新的药物洗脱支架（DES），与标准的裸金属支架（BMS）相比，是否具有成本效益？否。是否存在具有特定益处的特定患者亚组？是。提出了“有针对性的支架使用”用于日常实践。 DES的长期安全性是什么？观察到意外的安全问题。这是一个发现的机会吗？不会。但是，通过改进的支架技术，更新的支架和强化的抗血小板方案，可以将后期问题降到最低，如BASKET-PRO观点验证测试（BASKET-PROVE）所示。进一步的支架发展？等着瞧！ -提出并回答了许多其他问题，或者仍在调查中。显然，答案并不总是那么简单，需要仔细研究，对此进行了讨论。 BASKET试验不仅从一个问题到另一个问题，而且在规模和方法上都进行了。从受限的单中心“本地” BASKET研究到多中心国际长期试验，所有前瞻性，随机和研究者驱动。主要医学期刊上的出版物以及它们对美国和欧洲实践指南以及DES研究的影响都认可了它们的相关性。本综述总结了这些方面，重点介绍了每项研究的经验教训，并评论了在瑞士开展此类临床研究的可能性和困难。

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