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首页> 外文期刊>Swiss medical weekly: official journal of the Swiss Society of Infectious Diseases, the Swiss Society of Internal Medicine, the Swiss Society of Pneumology >Interferon therapy of hepatitis C: molecular insights into success and failure.
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Interferon therapy of hepatitis C: molecular insights into success and failure.

机译：丙型肝炎的干扰素治疗：成功与失败的分子洞察力。

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摘要

20 years have passed since the discovery of the hepatitis C virus (HCV), and yet therapeutic options remain limited. Current standard treatment of chronic hepatitis C (CHC) consists of pegylated interferon alpha (pegIFN) and ribavirin, and leads to a sustained virological response in approximately half of treated patients. Understanding non-responsiveness to pegIFN, by analysing the molecular mechanisms underlying treatment failure, is important for future therapeutic improvements. In the following review the current status of knowledge on the crosstalk between HCV and IFNs, as well as on the molecular events occurring in liver tissue of HCV-infected patients in response to pegIFN, is discussed. Furthermore, the review focuses on the prospect of developing a prognostic test that might direct treatment to those patients who will benefit from it. The outlook on novel therapeutics, including small molecule inhibitors of HCV proteins and immune modulators, is broadened by a glance at the exciting field of micro-RNAs that are likely to be implicated in viral replication and pathogenesis of CHC, thus representing a new therapeutic target.
机译：自发现丙型肝炎病毒（HCV）以来已有20年了，但治疗选择仍然有限。当前的慢性丙型肝炎（CHC）的标准治疗方法包括聚乙二醇化干扰素α（pegIFN）和利巴韦林，在大约一半的患者中导致持续的病毒学应答。通过分析治疗失败背后的分子机制，了解对pegIFN的无反应性对于将来的治疗改进非常重要。在下面的综述中，讨论了有关HCV与IFN之间的串扰以及对HCV感染患者的肝组织中发生的针对pegIFN的分子事件的认识的最新知识。此外，本综述着重于开发预后测试的前景，该预后测试可能将治疗直接引向受益于该方法的患者。乍一看，可能涉及病毒复制和CHC发病机制的微小RNA令人兴奋的领域扩大了包括HCV蛋白小分子抑制剂和免疫调节剂在内的新型治疗方法的前景，从而代表了一种新的治疗靶标。

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