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首页> 外文期刊>Pediatric neurology >Modeling developmental plasticity after perinatal stroke: Defining central therapeutic targets in cerebral palsy
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Modeling developmental plasticity after perinatal stroke: Defining central therapeutic targets in cerebral palsy

机译：围产期中风后发育可塑性建模：定义脑瘫的主要治疗目标

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Perinatal stroke is presented as the ideal human model of developmental neuroplasticity. The precise timing, mechanisms, and locations of specific perinatal stroke diseases provide common examples of well defined, focal, perinatal brain injuries. Motor disability (hemiparetic cerebral palsy) constitutes the primary adverse outcome and the focus of models explaining how motor systems develop in health and after early injury. Combining basic science animal work with human applied technology (functional magnetic resonance imaging, diffusion tensor imaging, and transcranial magnetic stimulation), a model of plastic motor development after perinatal stroke is presented. Potential central therapeutic targets are revealed. The means to measure and modulate these targets, including evidence-based rehabilitation therapies and noninvasive brain stimulation, are suggested. Implications for clinical trials and future directions are discussed.
机译：围产期卒中被认为是人类发育神经可塑性的理想模型。特定的围产期中风疾病的确切时机，机制和位置提供了明确定义的局灶性围产期脑损伤的常见示例。运动障碍（偏瘫性脑瘫）是主要的不良后果，也是解释运动系统如何在健康和早期伤害后发展的模型的重点。将基础科学动物工作与人类应用技术（功能磁共振成像，弥散张量成像和经颅磁刺激）相结合，提出了围产期中风后可塑性运动发展的模型。揭示了潜在的中心治疗靶标。建议测量和调节这些目标的方法，包括基于证据的康复治疗和非侵入性脑刺激。讨论了对临床试验的影响和未来的方向。

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