Focal Cortical Dysplasia

Gaitanis John N.; Donahue John

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Focal Cortical Dysplasia

机译：局灶性皮质发育不良

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Focal cortical dysplasias are among the most common causes of intractable epilepsy in children. As the neuropathology of these conditions has been better clarified, the nomenclature has undergone numerous revisions. Their recognition has grown with the use of neuroimaging, and recent advances in imaging technology will further improve detection. Clinical, electroencephalographic, and imaging findings are often diagnostic, so it is imperative for the clinician to recognize the characteristic patterns. Treatment for developmental and behavioral disability remains largely symptomatic, and epilepsy medications are often ineffective. Epilepsy surgery, however, can be successful in selected patients. The basic science underlying the development of focal cortical dysplasias may lead to novel therapeutic approaches in the future. (C) 2013 Elsevier Inc. All rights reserved.

机译：局灶性皮质发育不良是儿童顽固性癫痫的最常见原因。由于这些病状的神经病理学已得到更好的阐明，因此术语已进行了许多修改。随着神经成像技术的使用，它们的识别度不断提高，并且成像技术的最新进展将进一步改善检测能力。临床，脑电图和影像学检查结果通常是诊断性的，因此临床医生必须识别特征性模式。发育和行为残疾的治疗仍主要是对症，癫痫药物通常无效。然而，癫痫手术在某些患者中可能是成功的。局灶性皮质发育异常的基础科学可能会在未来导致新的治疗方法。（C）2013 Elsevier Inc.保留所有权利。

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《Pediatric neurology》 |2013年第2期|共9页
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Gaitanis John N.; Donahue John;
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中图分类儿科学;
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1. Characteristics of MEG and MRI between Taylor's focal cortical dysplasia (type II) and other cortical dysplasia: surgical outcome after complete resection of MEG spike source and MR lesion in pediatric cortical dysplasia. [J] . Widjaja E, Otsubo H, Raybaud C, Epilepsy research . 2008,第2a3期

机译：泰勒局灶性皮质发育不良（II型）与其他皮质发育不良之间的MEG和MRI特征：小儿皮质发育不良的MEG尖峰源和MR病变完全切除后的手术结局。
2. Changes in vascular density in resected tissue of 97 patients with mild malformation of cortical development, focal cortical dysplasia or TSC‐related cortical tubers [J] . Veersema Tim J., Neef Andrew, Scheppingen Jackelien, International journal of developmental neuroscience: the official journal of the International Society for Developmental Neuroscience . 2019,第期

机译：97例皮质发育轻微畸形的97例患者切除组织中血管密度的变化，局灶性皮质发育不良或TSC相关皮质块茎
3. Recent Advances in Epilepsy Surgery and Achieving Best Outcomes Using High-Frequency Oscillations, Diffusion Tensor Imaging, Magnetoencephalography, Intraoperative Neuromonitoring, Focal Cortical Dysplasia, and Bottom of Sulcus Dysplasia [J] . Timoney Nessa, Rutka James T. Clinical neurosurgery. . 2017,第CNasuppla1期

机译：高频振荡，扩散张量成像，脑磁图，术中神经监测，局灶性皮质发育不良和沟底部发育不良在癫痫手术和实现最佳结果方面的最新进展
4. Improved Segmentation of Focal Cortical Dysplasia Lesions on MRI Using Expansion Towards Cortical Boundaries [C] . Colliot, O., Mansi, . 2006

机译：使用向皮质边界扩展的MRI聚焦皮质发育不良病变的改进分割
5. Categorizing Cortical Dysplasia Lesions for Surgical Outcome Using Network Functional Connectivity [D] . Bdaiwi, Abdullah Sarray. 2017

机译：使用网络功能连接性对皮质发育不良病变进行手术结果分类
6. Mammalian Target of Rapamycin (mTOR) Activation In Focal Cortical Dysplasia and Related Focal Cortical Malformations [O] . Michael Wong -1

机译：哺乳动物的雷帕霉素（MTOR）靶向局灶性皮质发育性的激活及相关焦皮质畸形
7. Mammalian target of rapamycin (mTOR) activation in focal cortical dysplasia and related focal cortical malformations [O] . Michael Wong 2013

机译：哺乳动物的雷帕霉素（MTOR）靶向局灶性皮质发育性的激活及相关焦皮质畸形

Focal Cortical Dysplasia

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