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首页> 外文期刊>Pediatric blood & cancer >Prognostic impact of cytogenetic abnormalities in children and adolescents with mature B-cell non-Hodgkin lymphoma: A report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG)
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Prognostic impact of cytogenetic abnormalities in children and adolescents with mature B-cell non-Hodgkin lymphoma: A report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG)

机译：细胞遗传学异常对患有成熟B细胞非霍奇金淋巴瘤的儿童和青少年的预后影响：日本小儿白血病/淋巴瘤研究组（JPLSG）的报告

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摘要

Little information is available on cytogenetic abnormalities and their prognostic importance in childhood mature B-cell non-Hodgkin lymphoma (B-NHL). We performed a review of 79 abnormal karyotypes in childhood B-NHL treated by a uniform protocol. Del(17p) was independently associated with significantly inferior event-free survival in Burkitt or Burkitt-like lymphoma. The adverse prognosis of MYC/8q24 rearrangement, +7q or del(13q), was not observed, which had been suggested as risk factors in FAB/LMB96. Our results imply the possible existence of a biological difference among ethnicities and should be useful to narrow down the gene causing poor prognosis in childhood B-NHL. Pediatr Blood Cancer 2015;62:1294-1296. (c) 2015 Wiley Periodicals, Inc.
机译：关于细胞遗传学异常及其在儿童期成熟的B细胞非霍奇金淋巴瘤（B-NHL）中的预后重要性，鲜有相关信息。我们对采用统一方案治疗的儿童期B-NHL的79种异常核型进行了综述。 Del（17p）独立地与Burkitt或Burkitt样淋巴瘤的无事件生存期显着降低相关。没有观察到MYC / 8q24重排，+ 7q或del（13q）的不良预后，这被认为是FAB / LMB96的危险因素。我们的结果暗示种族之间可能存在生物学差异，应该有助于缩小导致儿童B-NHL预后不良的基因。小儿血液癌2015; 62：1294-1296。 （c）2015年威利期刊有限公司

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