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首页> 外文期刊>Pediatric cardiology >Is family history of premature cardiovascular diseases appropriate for detection of dyslipidemic children in population-based preventive medicine programs? CASPIAN study.
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Is family history of premature cardiovascular diseases appropriate for detection of dyslipidemic children in population-based preventive medicine programs? CASPIAN study.

机译：早发性心血管疾病的家族史是否适合在以人群为基础的预防医学计划中检测血脂异常儿童？ CASPIAN研究。

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The objectives of this study were to determine the prevalence of dyslipidemia and the usefulness of self-report family history (FH) of premature cardiovascular disease (CVD) for identifying children with lipid disorders.This study was conducted on a representative, population-based sample of 4811 Iranian children and adolescents (2248 boys and 2563 girls) aged 6-18 years. We compared the obtained serum lipid profile with that of the Lipid Research Clinic (LRC) and calculated the predictive value of FH for detecting those children with dyslipidemia.Overall, for both genders and for age groups, the mean serum triglycerides (TG) and its percentiles were significantly higher, and the mean and percentiles of total, low-density, and high-density cholesterol (TC, LDL-C, and HDL-C respectively) were significantly lower than the LRC values. In total, 45.7% of participants had dyslipidemia; the most frequent ones were low HDL-C (24.8%) and hypertriglyceridemia (24.5%), followed by hypercholesterolemia (6.4%) andhigh LDL-C (6.3%), respectively. The mean serum lipid levels and the anthropometric measures were not significantly different among those with or without positive FH. The sensitivity, and specificity, positive and negative predictive values for FH in detecting those children with dyslipidemia were 28.4, 70.3. 44.7, and 53.8%, respectively.The usefulness of FH in identifying dyslipidemic children was relatively low. The common lipid disorders in our community were the components of the metabolic syndrome. We suggest that the current guidelines for screening lipid disorders in youths, which are based on cholesterol, should consider such ethnic differences.
机译：这项研究的目的是确定血脂异常的患病率，以及早发性心血管疾病（CVD）的自我报告家族史（FH）对识别脂质异常儿童的有用性。 6岁至18岁的4811名伊朗儿童和青少年（2248名男孩和2563名女孩）。我们将获得的血清脂质谱与脂质研究诊所（LRC）的脂质谱进行比较，并计算出FH对检测这些血脂异常儿童的预测价值。总体上，无论性别和年龄组，平均血清甘油三酸酯（TG）及其百分位数显着更高，总胆固醇，低密度胆固醇和高密度胆固醇（分别为TC，LDL-C和HDL-C）的平均值和百分位数显着低于LRC值。共有45.7％的参与者患有血脂异常;最常见的是低HDL-C（24.8％）和高甘油三酯血症（24.5％），其次是高胆固醇血症（6.4％）和高LDL-C（6.3％）。在有或没有FH阳性者中，平均血脂水平和人体测量指标无显着差异。 FH检测血脂异常儿童的敏感性，特异性，阳性和阴性预测值分别为28.4、70.3。 FH分别在识别血脂异常儿童中的有用性相对较低，分别为44.7和53.8％。我们社区中常见的脂质疾病是代谢综合征的组成部分。我们建议，当前基于胆固醇的年轻人脂质障碍筛查指南应考虑这种种族差异。

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