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首页> 外文期刊>Pediatric Pulmonology >Assessment of airway function in young children with asthma: comparison of spirometry, interrupter technique, and tidal flow by inductance plethsmography.
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Assessment of airway function in young children with asthma: comparison of spirometry, interrupter technique, and tidal flow by inductance plethsmography.

机译：哮喘患儿气道功能的评估：电感容积描记法比较肺活量测定法，间断技术和潮气量。

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The assessment of airway function in young children requires adaptation of techniques designed for adults and/or application of techniques that do not require complex respiratory maneuvers. We sought to assess two methods of measuring airway function: time to peak expiratory flows as a ratio of expiratory time (T(PTEF)/T(E)), derived from respiratory inductance plethysmography, and total respiratory resistance by the interrupter technique (Rint), both obtained during quiet tidal breathing. Both techniques were referenced to FEV1 and flow at 50% expired volume (FEF50) from conventional spirometry in 30 children aged 4-8 years (median age, 6.9; range, 4.5-8.5 years) with a physician diagnosis of asthma and who were able to perform FEV1 with a repeatability of at least 8%. T(PTEF)/T(E) and Rint were performed in random order followed by spirometry, in order to reduce the possible effects of pulmonary stretch on tidal breathing measures. Coefficients of variation (CV) and mean absolute change/baseline standard deviation were derived for each measurement. Baseline FEV1 did not correlate significantly with T(PTEF)/T(E) (r = 0.025), but did correlate with Rint (r = 0.737, P < 0.001); respective relationships for change after bronchodilator were r = 0.09 (ns) and r = 0.64 (P < 0.001). FEF50 also correlated significantly with Rint (R = 0.769, P < 0.001) but not with T(PTEF)/T(E). FEV1 and FEF50 both increased postbronchodilator, with respective mean changes of 11.4% and 28% (P < 0.001), while Rint decreased by 24.3% (P < 0.001). No significant changes were noted for T(PTEF)/T(E). T(PTEF)/T(E) derived from inductance plethysmography does not detect mild airway obstruction or modest changes in airway caliber following bronchodilator in young children with asthma. The interrupter technique may have a role in assessing baseline airway function and response to therapy in children unable to perform reliable spirometry, and/or when the investigator wishes to avoid the possible influence of forced maneuvers on airway tone.
机译：对幼儿气道功能的评估需要适应为成人设计的技术和/或应用不需要复杂呼吸操作的技术。我们试图评估两种测量气道功能的方法：呼气高峰时间与呼气时间之比（T（PTEF）/ T（E））（通过呼吸感应体积描记法得出）和通过中断器技术获得的总呼吸阻力（Rint ），都是在安静的潮气呼吸过程中获得的。两种技术均以FEV1为参考，并在常规诊断中以常规肺活量测定法以50％的过期体积流量（FEF50）在30岁4-8岁（中位年龄为6.9;范围为4.5-8.5岁）的儿童中诊断为哮喘，并且能够执行FEV1的重复性至少为8％。 T（PTEF）/ T（E）和Rint按随机顺序进行，然后进行肺活量测定，以减少肺部拉伸对潮气呼吸措施的可能影响。每次测量均得出变异系数（CV）和平均绝对变化/基线标准偏差。基线FEV1与T（PTEF）/ T（E）没有显着相关（r = 0.025），但与Rint相关（r = 0.737，P <0.001）。支气管扩张剂后变化的各自关系为r = 0.09（ns）和r = 0.64（P <0.001）。 FEF50也与Rint显着相关（R = 0.769，P <0.001），但与T（PTEF）/ T（E）不相关。 FEV1和FEF50均增加了支气管扩张剂，平均变化分别为11.4％和28％（P <0.001），而Rint下降了24.3％（P <0.001）。 T（PTEF）/ T（E）没有显着变化。电感体积描记法得出的T（PTEF）/ T（E）不能检测出哮喘小儿支气管扩张剂后的轻度气道阻塞或气道口径的适度变化。对于无法执行可靠的肺活量测定的儿童，和/或当研究者希望避免强制性操作对气道音调的可能影响时，灭弧室技术可能在评估基线气道功能和对治疗的反应中起作用。

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