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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Rotavirus vaccines and health care utilization for diarrhea in the United States (2007-2011)
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Rotavirus vaccines and health care utilization for diarrhea in the United States (2007-2011)

机译：美国轮状病毒疫苗和用于腹泻的医疗保健利用（2007-2011年）

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OBJECTIVES: To examine reductions in diarrhea-associated health care utilization after rotavirus vaccine implementation and to assess direct and indirect effectiveness of vaccination. METHODS: Retrospective cohort analysis of claims data of commercially insured US children aged <5 years. We examined annual pentavalent (RV5) and monovalent (RV1) rotavirus vaccine coverage. We compared rates of diarrhea-associated health care utilization in prevaccine (2001-2006) versus postvaccine introduction (2007-2011) years, compared rates of diarrhea-associated health care utilization in vaccinated versus unvaccinated children and compared rates in unvaccinated children in postvaccine versus prevaccine years. RESULTS: Among children aged <5 years, RV5 and RV1 rotavirus vaccine coverage rates reached 58% and 5%, respectively, by December 31, 2010. Compared with the average rate of rotavirus-coded hospitalizations in 2001-2006, rates were reduced by 75% in 2007-2008, 60% in 2008-2009, 94% in 2009-2010, and 80% in 2010-2011. Compared with unvaccinated children, in 2010-2011, the rate of rotavirus-coded hospitalizations was reduced by 92% among RV5 recipients and 96% among RV1 recipients. Rotavirus-coded hospitalization rate reductions among RV5 recipients versus unvaccinated children ranged from 87% among <1-year-olds to 81% among 4-year-olds. Compared with prevaccine rates in 2001-2006, rotavirus-coded hospitalization rates among unvaccinated children decreased by 50% in 2007-2008, 77% in 2009-2010, and 25% in 2010-2011. CONCLUSIONS: Implementation of rotavirus vaccines has substantially reduced diarrhea health care utilization in US children. Both rotavirus vaccines conferred high protection against rotavirus hospitalizations; RV5 conferred durable protection through the fourth year of life. Vaccination also conferred indirect benefits to unvaccinated children.
机译：目的：研究轮状病毒疫苗实施后与腹泻有关的卫生保健利用的减少，并评估疫苗接种的直接和间接有效性。方法：对年龄在5岁以下的商业保险美国儿童的索赔数据进行回顾性队列分析。我们检查了年度五价（RV5）和单价（RV1）轮状病毒疫苗覆盖率。我们比较了疫苗接种前（2001-2006）与疫苗接种后（2007-2011）年的腹泻相关卫生保健利用率，疫苗接种与未接种疫苗的儿童腹泻相关卫生保健利用率以及疫苗接种与未接种疫苗的未接种腹泻儿童的比例。疫苗接种前的岁月。结果：到2010年12月31日，在5岁以下的儿童中，RV5和RV1轮状病毒疫苗的覆盖率分别达到58％和5％。与2001-2006年轮状病毒编码住院的平均比率相比，该比率降低了2007-2008年为75％，2008-2009年为60％，2009-2010年为94％，2010-2011年为80％。与未接种疫苗的儿童相比，2010-2011年轮状病毒编码的住院患者在RV5接受者中减少了92％，在RV1接受者中减少了96％。轮状病毒编码的RV5接受者与未接种疫苗的儿童之间的住院率降低幅度，范围从<1岁儿童的87％到4岁儿童的81％。与2001-2006年的疫苗接种率相比，未接种疫苗的儿童中轮状病毒编码的住院率在2007-2008年下降了50％，在2009-2010年下降了77％，在2010-2011年下降了25％。结论：轮状病毒疫苗的实施已大大降低了美国儿童的腹泻医疗保健利用率。两种轮状病毒疫苗都具有针对轮状病毒住院的高度保护; RV5在使用寿命的第四年内提供了持久的保护。接种疫苗还给未接种疫苗的儿童带来间接好处。

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