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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Survival and morbidity outcomes for very low birth weight infants with Down syndrome.
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Survival and morbidity outcomes for very low birth weight infants with Down syndrome.

机译：患有唐氏综合症的极低出生体重婴儿的生存率和发病率结果。

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OBJECTIVE: Our objective was to compare survival and neonatal morbidity rates between very low birth weight (VLBW) infants with Down syndrome (DS) and VLBW infants with non-DS chromosomal anomalies, nonchromosomal birth defects (BDs), and no chromosomal anomaly or major BD. METHODS: Data were collected prospectively for infants weighing 401 to 1500 g who were born and/or cared for at one of the study centers participating in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network in 1994-2008. Risk of death and morbidities, including patent ductus arteriosus (PDA), necrotizing enterocolitis (NEC), late-onset sepsis (LOS), retinopathy of prematurity, and bronchopulmonary dysplasia (BPD), were compared between VLBW infants with DS and infants in the other groups. RESULTS: Infants with DS were at increased risk of death (adjusted relative risk: 2.47 [95% confidence interval: 2.00-3.07]), PDA, NEC, LOS, and BPD, relative to infants with no BDs. Decreased risk of death (relative risk: 0.40 [95% confidence interval: 0.31-0.52]) and increased risks of NEC and LOS were observed when infants with DS were compared with infants with other non-DS chromosomal anomalies. Relative to infants with nonchromosomal BDs, infants with DS were at increased risk of PDA and NEC. CONCLUSION: The increased risk of morbidities among VLBW infants with DS provides useful information for counseling parents and for anticipating the need for enhanced surveillance for prevention of these morbidities.
机译：目的：我们的目的是比较唐氏综合症（DS）的极低出生体重（VLBW）婴儿和非DS染色体异常，非染色体出生缺陷（BDs），无染色体异常或严重的VLBW婴儿的生存率和新生儿发病率BD。方法：前瞻性收集1994-2008年在Eunice Kennedy Shriver国家儿童健康与人类发展新生儿研究所网络研究中心之一的研究中心出生和/或照顾的401至1500 g婴儿的数据。比较了VLBW DS患儿和DSB患儿的死亡和发病风险，包括动脉导管未闭（PDA），坏死性小肠结肠炎（NEC），迟发性败血症（LOS），早产儿视网膜病变和支气管肺发育不良（BPD）。其他组。结果：相对于没有BD的婴儿，DS婴儿的死亡风险增加（校正后的相对危险度：2.47 [95％可信区间：2.00-3.07]），PDA，NEC，LOS和BPD升高。当将DS婴儿与其他非DS染色体异常婴儿进行比较时，观察到死亡风险降低（相对风险：0.40 [95％置信区间：0.31-0.52]），NEC和LOS风险增加。相对于非染色体BD婴儿，DS婴儿患PDA和NEC的风险增加。结论：患有DS的VLBW婴儿患病风险增加，为指导父母和预期需要加强监测以预防这些疾病提供有用的信息。

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