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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >High incidence of invasive group B streptococcal infections in HIV-exposed uninfected infants.
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High incidence of invasive group B streptococcal infections in HIV-exposed uninfected infants.

机译：暴露于HIV的未感染婴儿中，侵入性B组链球菌感染的发生率很高。

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摘要

OBJECTIVES: The occurrence of an unusual number of group B streptococcal (GBS) infections in HIV-exposed uninfected (HEU) infants who were followed in our center prompted this study. The objective of this study was to describe and compare the incidence and clinical presentation of GBS infections in infants who were born to HIV-infected and -uninfected mothers. METHODS: All cases of invasive GBS infections in infants who were born between 2001 and 2008 were identified from the database of HEU infants and from the microbiology laboratory records. The medical charts of all infants with GBS infection were reviewed. RESULTS: GBS invasive infections were described for 5 (1.55%) infants who were born to 322 HIV-infected mothers who delivered in our center. The incidence of GBS infections during the same period was 16 (0.08%) of 20 158 infants who were born to HIV-uninfected mothers. One HEU infant presented a recurrent infection 28 days after completion of treatment for the first episode. Late-onset infection was more frequent in HEU infants (5 of 6 vs 2 of 16 episodes in the control population). The diseases were also more severe in HEU infants with 5 of 6 sepsis or sepsis shock in HEU infants versus 10 of 16 in control subjects, and most HEU infants had leukopenia at onset of infection. CONCLUSIONS: The incidence of GBS infection was significantly higher in HEU infants than in infants who were born to HIV-uninfected mothers. These episodes of GBS sepsis in HEU infants were mostly of late onset and more severe than in the control population, suggesting an increased susceptibility of HEU infants to GBS infection.
机译：目的：在我们中心接受随访的HIV感染未感染（HEU）婴儿中，发生了异常数量的B组链球菌（GBS）感染。这项研究的目的是描述和比较感染HIV和未感染HIV的母亲所生婴儿的GBS感染的发生率和临床表现。方法：从HEU婴儿数据库和微生物学实验室记录中鉴定出2001年至2008年之间出生的所有GBS侵袭性感染病例。回顾了所有患有GBS感染的婴儿的病历。结果：描述了5名（1.55％）婴儿的GBS侵袭性感染，这些婴儿是由322名感染HIV的母亲所生，这些母亲在我们中心分娩。同期，未感染艾滋病毒的母亲所生的20 158名婴儿中，GBS感染的发生率为16（占0.08％）。一名HEU婴儿在完成首例治疗后28天出现了反复感染。在HEU婴儿中，晚发型感染更为频繁（对照组中6例中有5例，有16例中有2例）。在HEU婴儿中，这种疾病也更为严重，在HEU婴儿中有5分之6的败血症或脓毒症休克，而在对照受试者中有16分之10，而且大多数HEU婴儿在感染开始时就有白细胞减少症。结论：HEU婴儿中GBS感染的发生率明显高于未感染HIV的母亲所生的婴儿。 HEU婴儿的这些GBS败血症发作较晚，并且比正常人群更为严重，表明HEU婴儿对GBS感染的敏感性增加。

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