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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Outcome of early-onset sepsis in a national cohort of very low birth weight infants.
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Outcome of early-onset sepsis in a national cohort of very low birth weight infants.

机译：极低出生体重婴儿的全国队列中早发败血症的结果。

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摘要

BACKGROUND: Early-onset sepsis (EOS) is associated with significant morbidity and mortality among infants with a very low birth weight (VLBW); however, there is a sparse amount of complete data on large cohorts. OBJECTIVE: To evaluate the mortality and major morbidities among VLBW infants with EOS. METHODS: This was a population-based observational study. Data were prospectively collected by the Israel Neonatal Network on all VLBW infants born in Israel from 1995 through 2005. Univariate and multivariable analyses were performed to assess the independent association of EOS on morbidity and mortality of VLBW infants. RESULTS: The study cohort included 15 839 infants, of whom 383 (2.4%) developed EOS. EOS was associated with significantly increased odds for mortality (odds ratio [OR]: 2.57 [95% confidence interval (CI): 1.97-3.35]), severe intraventricular hemorrhage (OR: 2.24 [95% CI: 1.67-3.00]), severe retinopathy of prematurity (OR: 2.04 [95% CI: 1.32-3.16]), and bronchopulmonary dysplasia (OR: 1.74 [95% CI: 1.24-2.43]). EOS was associated with an increased risk of death and/or severe neurologic morbidity (OR: 2.92 [95% CI: 2.27-3.80]). CONCLUSIONS: Although only 2.4% of VLBW infants had an episode of EOS, these infants were at an approximately threefold excess risk of death or major neurologic morbidities.
机译：背景：早产脓毒症（EOS）与极低出生体重（VLBW）的婴儿的发病率和死亡率显着相关。但是，有关大型队列的完整数据很少。目的：评估VLOSW婴儿EOS的死亡率和主要发病率。方法：这是一项基于人群的观察性研究。以色列新生儿网络前瞻性收集了1995年至2005年在以色列出生的所有VLBW婴儿的数据。进行了单因素和多变量分析，以评估EOS对VLBW婴儿的发病率和死亡率的独立关联。结果：该研究队列包括15 839名婴儿，其中383名（2.4％）患有EOS。 EOS与死亡率几率显着增加（赔率[OR]：2.57 [95％置信区间（CI）：1.97-3.35]），严重的脑室内出血（OR：2.24 [95％CI：1.67-3.00]）相关，严重的早产儿视网膜病变（OR：2.04 [95％CI：1.32-3.16]）和支气管肺发育不良（OR：1.74 [95％CI：1.24-2.43]）。 EOS与死亡和/或严重神经系统疾病的风险增加相关（OR：2.92 [95％CI：2.27-3.80]）。结论：尽管只有2.4％的VLBW婴儿发生EOS，但这些婴儿的死亡或重大神经系统疾病的风险大约是其三倍。

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