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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Mercury content of blood transfusions for infants with extremely low birth weight.
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Mercury content of blood transfusions for infants with extremely low birth weight.

机译：出生体重极低的婴儿的输血中汞含量。

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摘要

OBJECTIVES: To assess whether blood transfusions for infants with birth weights of 1000 g or less are a source of mercury and whether any mercury delivered through the transfusion is above the currently set oral reference dose. PATIENTS AND METHODS: We studied an observational cohort. Inclusion criteria included birth weight 1000 g or less and receipt of 1 or more packed red blood cell transfusions. Packed red blood cell units were tested prospectively for mercury levels. The quantity of transfused mercury was calculated on the basis of transfused volume and packed red blood cell mercury level. The resulting mercury level was compared with the reference dose as set by the Agency for Toxic Substances and Disease Registry, the World Health Organization, and the US Environmental Protection Agency. RESULTS: Thirty-seven infants (birth weight: 736 +/- 157 g; gestational age: 25.5 +/- 1.5 weeks) met the inclusion criteria. A total of 325 transfusions from 49 packed red blood cell units were administered. Mercury was detected in 40 units. The average mercury level in a packed red blood cell unit was 1.9 +/- 2.6 mug/L (median: 0.9 mug/L [interquartile range: 0.3-2.5]). None of the infants received any mercury above the reference dose set by the Agency for Toxic Substances and Disease Registry and the World Health Organization. Twelve infants received 1 transfusion, and 5 infants received 2 transfusions above the Environmental Protection Agency reference dose during their entire hospitalization. CONCLUSIONS: Packed red blood cells are a source of mercury for infants. However, the amount delivered is low compared with currently set safety levels. The episodes in which mercury intake exceeded the reference dose were rare. However, without long-term follow-up, no conclusions can be made about the cognitive implications of these episodes.
机译：目的：评估出生体重在1000 g或以下的婴儿的输血是否是汞的来源，以及通过输血输送的任何汞是否超过当前设定的口服参考剂量。患者与方法：我们研究了一个观察性队列。纳入标准包括出生体重不超过1000克，以及接受1次或多次包装的红细胞输血。对包装好的红细胞单元进行了汞含量的前瞻性测试。根据输血量和堆积的红细胞汞含量计算出输汞量。将产生的汞含量与有毒物质和疾病登记局，世界卫生组织和美国环境保护局设定的参考剂量进行比较。结果：三十七名婴儿（出生体重：736 +/- 157克;胎龄：25.5 +/- 1.5周）符合纳入标准。总共从49个包装的红细胞单元中进行了325次输血。在40个单位中检测到汞。填充红细胞单元中的平均汞含量为1.9 +/- 2.6马克杯/升（中位数：0.9马克杯/升[四分位数范围：0.3-2.5]）。没有任何婴儿接受超过有毒物质和疾病登记局和世界卫生组织设定的参考剂量的汞。在整个住院期间，有12名婴儿接受了1次输血，5名婴儿接受了超过环境保护局参考剂量的2次输血。结论：包装的红细胞是婴儿的汞来源。但是，与当前设置的安全级别相比，交付的数量很少。汞摄入超过参考剂量的情况很少见。但是，如果没有长期随访，就无法得出这些发作的认知意义的结论。

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