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Cell therapy: A novel treatment approach for bronchopulmonary dysplasia

机译：细胞疗法：支气管肺发育不良的新型治疗方法

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摘要

Bronchopulmonary dysplasia (BPD) is a major cause of substantial lifelong morbidity in preterm infants. Despite a better understanding of the pathophysiology of BPD and significant research effort into its management, there remains today no effective treatment. Cell-based therapy is a novel approach that offers much promise in the prevention and treatment of BPD. Recent research supports a therapeutic role for cell transplantation in the management of a variety of acute and chronic adult and childhood lung diseases, with potential of such therapy to reduce inflammation and prevent acute lung injury. However, considerable uncertainties remain regarding cell therapies before they can be established as safe and effective clinical treatments for BPD. This review summarizes the current literature investigating cell therapies in lung disease, with particular focus on the various types of cells available and their specific properties in the context of a future therapy for BPD.
机译：支气管肺发育不良（BPD）是早产儿大量终身发病的主要原因。尽管对BPD的病理生理学有了更好的了解，并对其管理进行了大量研究工作，但今天仍然没有有效的治疗方法。基于细胞的疗法是一种新颖的方法，为BPD的预防和治疗提供了广阔的前景。最近的研究支持细胞移植在各种急性和慢性成人和儿童肺部疾病的治疗中的治疗作用，这种治疗具有减轻炎症和预防急性肺损伤的潜力。然而，在将细胞疗法确定为BPD的安全有效临床治疗之前，关于细胞疗法的不确定性仍然很大。这篇综述总结了研究肺疾病中细胞疗法的最新文献，特别着眼于在BPD未来疗法的背景下可获得的各种类型的细胞及其特异性。

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