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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Analgesic effect of breast milk versus sucrose for analgesia during heel lance in late preterm infants
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Analgesic effect of breast milk versus sucrose for analgesia during heel lance in late preterm infants

机译：母乳与蔗糖对晚期早产儿足跟采血时的镇痛作用

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OBJECTIVE: The purpose of this trial was to investigate whether breast milk (either breastfed or bottle-fed) has a better analgesic effect than sucrose in newborns born at a postmenstrual age between 32 and 37 weeks. METHODS: We conducted a randomized controlled trial at a secondary care neonatal unit in the Netherlands on 71 preterm neonates (postmenstrual age at birth 32-37 weeks), undergoing heel lance with an automated piercing device. Newborns were randomly assigned to breast milk (either breastfed or bottle-fed) administered during heel lance or oral sucrose administered before heel lance. We assessed the Premature Infant Pain Profile (PIPP) score (range, 0-21) to investigate whether there was a difference in pain score between neonates receiving breast milk and those receiving sucrose solution. RESULTS: There was no significant difference in mean PIPP score between neonates receiving breast milk (6.1) and those receiving sucrose (5.5), with a mean difference of 0.6 (95% confidence interval 21.6 to 2.8; P = .58). CONCLUSIONS: From this study, it cannot be concluded that breast milk has a better analgesic effect than sucrose in late preterm infants. From the results, it follows with 95% confidence that the analgesic effect of breast milk is not >1.6 points better and not >2.8 points worse on the PIPP scale (SD 3.7) than the analgesic effect of sucrose in late preterm infants.
机译：目的：本研究的目的是调查在月经后32至37周出生的婴儿，母乳（母乳喂养或瓶装喂养）的镇痛作用是否比蔗糖好。方法：我们在荷兰的二级保健新生儿室进行了一项随机对照试验，对71名早产儿（出生后月经后32-37周）进行了自动穿刺装置的足跟采血。新生儿被随机分配到在脚跟长矛术中施用的母乳（母乳喂养或瓶装喂养）或在脚跟长矛术之前施用的口服蔗糖。我们评估了早产儿疼痛概况（PIPP）评分（范围0-21），以调查接受母乳的婴儿和接受蔗糖溶液的婴儿之间的疼痛评分是否存在差异。结果：接受母乳喂养的新生儿（6.1）和接受蔗糖喂养的新生儿（5.5）之间的平均PIPP评分无显着差异，平均差异为0.6（95％置信区间为21.6至2.8; P = .58）。结论：根据这项研究，不能得出结论，对于早产早产儿，母乳比蔗糖具有更好的镇痛作用。从结果可以得出95％的置信度，在PIPP量表（SD 3.7）上，母乳的镇痛效果不如蔗糖对晚期早产儿的镇痛效果好> 1.6分，并且不差> 2.8分（SD 3.7）。

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