...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Guidance on Management of Asymptomatic Neonates Born to Women With Active Genital Herpes Lesions
【24h】

Guidance on Management of Asymptomatic Neonates Born to Women With Active Genital Herpes Lesions

机译：生殖器疱疹活跃期妇女无症状新生儿的治疗指南

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The risk of transmitting herpes simplex virus (HSV) from mother to infant during delivery is determined, in part, by the mother's previous immunity to HSV. Women who have never had HSV type 1 (HSV-1) or HSV type 2 (HSV-2) and who acquire it during the latter part of pregnancy (primary genital infection) and shed virus at delivery are 10 to 30 times more likely to transmit the virus to their newborn infants than are women with recurrent HSV infection who are shedding virus at delivery. With the availability of commercial serological tests that can distinguish type-specific HSV antibodies reliably, it now is possible to determine the type of maternal infection and, thus, the relative risk of transmission to the neonate. This information then can be used to further refine management of infants born to women with active genital HSV lesions. The management algorithm presented in this clinical report (American Academy of Pediatrics. Clinical report: Guidance on management of asymptomatic neonates born to women with active genital herpes lesions. Pediatrics. 2013;131[2]:exxx-exxx. Available at: www.pediatrics.org/content/131/2/exxx.full) uses both serological and virological studies to determine risk of HSV transmission to the asymptomatic neonate who is born to a mother with active herpetic genital lesions and tailors management accordingly. Classification of maternal infection is aided with Table 1, and management approaches to exposed neonates are outlined in Figs 1 and 2. This algorithm should be applied only in facilities where access to polymerase chain reaction assay and type-specific serological testing are readily available and turnaround time for test results is appropriately short. In situations in which this is not possible, the approach detailed in the algorithm will have limited and, perhaps, no applicability. The algorithm does not address the approach to asymptomatic neonates born to women with a history of genital herpes but no active lesions at delivery.
机译：分娩过程中将单纯疱疹病毒（HSV）从母亲传播给婴儿的风险部分取决于母亲先前对HSV的免疫力。从未患过HSV 1型（HSV-1）或HSV 2型（HSV-2）且在妊娠后期（初次生殖器感染）并在分娩时染上病毒的妇女患上分娩病毒的可能性高10到30倍将这种病毒传播给新生婴儿的比例要比那些复发性HSV感染的妇女在分娩时会散发病毒的比例高。有了可以可靠地区分类型特异性HSV抗体的商业血清学检测，现在可以确定孕产妇感染的类型，从而可以确定其传播给新生儿的相对风险。然后，该信息可用于进一步完善具有活跃生殖器HSV病变的妇女所生婴儿的管理。本临床报告中介绍的管理算法（美国儿科学会。临床报告：具有活动性生殖器疱疹病灶的妇女无症状新生儿的治疗指南。儿科。2013; 131 [2]：exxx-exxx。可在以下网址获得： pediatrics.org/content/131/2/exxx.full）使用血清学和病毒学研究来确定将HSV传播给无症状新生儿的风险，该无症状新生儿是由活跃的疱疹性生殖器病变母亲所生，并据此进行管理。表1辅助了孕产妇感染的分类，图1和2概述了暴露的新生儿的管理方法。该算法仅应适用于容易获得聚合酶链反应测定和特定类型血清学检测且可以解决的设施测试结果的时间适当短。在不可能做到这一点的情况下，算法中详述的方法将具有局限性，并且可能没有适用性。该算法未解决针对具有生殖器疱疹史但分娩时无活动性病变的妇女无症状新生儿的治疗方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号