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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Environmental tobacco smoke and serum vitamin C levels in children.
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Environmental tobacco smoke and serum vitamin C levels in children.

机译：儿童的环境烟草烟雾和血清维生素C水平。

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BACKGROUND: High levels of free radicals in tobacco smoke are thought to be responsible for decreased levels of serum ascorbic acid in smokers and adults exposed to environmental tobacco smoke (ETS). The association of ETS to serum ascorbic acid in children is unknown. METHODS: Data were analyzed from the Third National Health and Nutrition Examination Survey, a nationally representative sample of children and adolescents (n = 2968). Comprehensive data including serum cotinine levels and family smoking patterns allowed for analysis of relationship of ETS to serum ascorbic acid levels. Data from 24-hour dietary recall also allowed for the control of vitamin C intake. Children were divided into categories of low and high ETS exposure based on levels of serum cotinine above or below 2 ng/mL. Smokers were defined by either self-report or serum cotinine >15 ng/mL. RESULTS: Although there was a trend for lower levels of vitamin C intake in children with higher levels of ETS exposure, this trend did not reach statistical significance. Among all children, serum ascorbic acid levels were linearly related to serum cotinine levels (r = 0.19). In addition, a dose-response relationship was observed between levels of tobacco exposure and serum ascorbic acid levels. After adjusting for age, gender, vitamin C intake, and multivitamin use, environmental tobacco exposure remained significantly associated with lower levels of serum ascorbic acid in children who were exposed to both high and low levels of ETS. CONCLUSION: Exposure of children to ETS leads to significant alterations in serum ascorbic acid levels. Therefore, this study further highlights the potential dangers of ETS to children.
机译：背景：烟草烟雾中的自由基水平高被认为是导致吸烟者和暴露于环境烟草烟雾（ETS）的成年人血清抗坏血酸水平下降的原因。 ETS与儿童血清抗坏血酸的关系尚不清楚。方法：对数据进行了第三次全国健康和营养检查调查，这是全国代表性的儿童和青少年样本（n = 2968）。包括血清可替宁水平和家庭吸烟模式在内的综合数据可用于分析ETS与血清抗坏血酸水平的关系。 24小时饮食召回的数据也可以控制维生素C的摄入量。根据血清可替宁高于或低于2 ng / mL的水平，将儿童分为低和高ETS暴露类别。吸烟者的定义为自我报告或血清可替宁> 15 ng / mL。结果：尽管有较高的ETS暴露水平的儿童，维生素C的摄入量有降低的趋势，但这种趋势没有统计学意义。在所有儿童中，血清抗坏血酸水平与血清​​可替宁水平呈线性相关（r = 0.19）。另外，在烟草暴露水平和血清抗坏血酸水平之间观察到剂量-反应关系。在调整了年龄，性别，维生素C摄入量和多种维生素的使用量之后，环境烟草暴露仍然与暴露于高水平和低水平ETS的儿童血清抗坏血酸水平降低显着相关。结论：儿童接触ETS会导致血清抗坏血酸水平发生显着变化。因此，本研究进一步强调了ETS对儿童的潜在危险。

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