...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Gender differences in lymphocyte populations, plasma HIV RNA levels, and disease progression in a cohort of children born to women infected with HIV.
【24h】

Gender differences in lymphocyte populations, plasma HIV RNA levels, and disease progression in a cohort of children born to women infected with HIV.

机译：感染艾滋病毒的妇女所生孩子队列中的淋巴细胞数量，血浆HIV RNA水平和疾病进展的性别差异。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: We sought to document gender differences in lymphocyte subsets and plasma RNA levels in a pediatric cohort with presumed minimal hormonal differences (on the basis of age). METHODS: Blood samples from antiretroviral therapy-treated, HIV-infected children (n = 158) and HIV-uninfected children (n = 1801) who were enrolled in the Women and Infants Transmission Study were analyzed at specified study intervals with consensus protocols, and various parameters were compared. RESULTS: Antiretroviral therapy-treated, HIV-infected female children had, on average, 0.38 log10 copies per mL lower plasma RNA levels than did their male counterparts, but lymphocyte differences were not noted in this cohort. Despite their higher plasma RNA level, a greater proportion of male children survived through 8 years of age. There were no gender differences with respect to the age of diagnosis of HIV, time to antiretroviral therapy after diagnosis of HIV, or type of antiretroviral therapy. Lymphocyte differences werenoted for uninfected children. CONCLUSIONS: Plasma RNA levels differed among antiretroviral therapy-treated, HIV-infected children according to gender, in a manner similar to that noted in previous pediatric and adult studies. Lymphocyte subsets varied according to gender in a cohort of HIV-exposed but uninfected children. Most importantly, overall mortality rates for this cohort differed according to gender.
机译：目的：我们试图记录儿童队列中淋巴细胞亚群和血浆RNA水平的性别差异，并假定其最小的激素差异（基于年龄）。方法：以特定的研究间隔和共识方案分析了参加妇女和婴儿传播研究的抗逆转录病毒疗法治疗的HIV感染儿童（n = 158）和HIV未感染儿童（n = 1801）的血样。比较了各种参数。结果：经抗逆转录病毒疗法治疗，感染了HIV的女童血浆RNA水平平均每mL比男性低0.38 log10拷贝/ mL，但该人群未发现淋巴细胞差异。尽管血浆RNA水平较高，但仍有较大比例的男孩存活到8岁。关于HIV的诊断年龄，HIV诊断后接受抗逆转录病毒治疗的时间或抗逆转录病毒治疗的类型，没有性别差异。未感染儿童注意到淋巴细胞差异。结论：根据性别，抗逆转录病毒疗法治疗的HIV感染儿童的血浆RNA水平不同，其方式与先前的儿科和成人研究中所述相同。艾滋病毒暴露但未感染儿童的淋巴细胞亚群根据性别而变化。最重要的是，该队列的总死亡率因性别而异。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号