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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Relationships of cardiovascular phenotypes with healthy weight, at risk of overweight, and overweight in US youths.
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Relationships of cardiovascular phenotypes with healthy weight, at risk of overweight, and overweight in US youths.

机译：美国年轻人中心血管表型与健康体重，有超重风险和超重的风险之间的关系。

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OBJECTIVE: This study aimed to evaluate comprehensively the cardiovascular phenotypes of cardiovascular disease-free youths at risk of overweight, in comparison with healthy weight and overweight. METHODS: Casual and ambulatory blood pressure measurements, noninvasive hemodynamic profiles, pulse wave velocity, left ventricular structure and function, and overnight sodium excretion were examined in a cohort of US black and white youths (n = 972; mean age: 17.6 +/- 3.3 years). RESULTS: The occurrence of at risk of overweight was approximately 17% in either black youths or white youths. In white youths, there was a approximately 2-mmHg increase in casual systolic blood pressure for each increasing step in the 3 BMI categories (healthy weight, 109.5 +/- 0.5 mmHg; at risk of overweight, 111.5 +/- 0.6 mmHg; overweight, 113.5 +/- 1.1 mmHg). Ambulatory systolic blood pressure showed a similar increase with the increase in BMI. A blunted nocturnal decline in ambulatory diastolic blood pressure with the categorical BMI increase was observed in black youths. In both racial groups, cardiac output and stroke volume were significantly enhanced sequentially from healthy weight to at risk of overweight to overweight. In black youths, both casual and ambulatory heart rate increased significantly with the increase in BMI. Moreover, there was a linear increase of left ventricular mass index from the healthy-weight group to the at risk of overweight group, with the overweight group having the highest value. In white youths, carotid-dorsalis pedis pulse wave velocity increased significantly as the BMI increased. Regardless of race, overnight sodium excretion showed a significant increase from healthy-weight subjects to overweight subjects, with at risk of overweight subjects having intermediate values. CONCLUSIONS: Youths at risk of overweight, compared with healthy-weight youths, seem to have increased cardiovascular risks. Our data suggest that the status of at risk of overweight already has clinical implications in youths.
机译：目的：本研究旨在全面评估与健康体重和超重相比，有超重风险的无心血管疾病青年的心血管表型。方法：在一组美国黑人和白人青年（n = 972;平均年龄：17.6 +/-）中检查了偶然和动态血压测量，无创血流动力学特征，脉搏波速度，左心室结构和功能以及夜间钠排泄。 3.3年）。结果：无论是黑人青年还是白人青年，超重风险的发生率约为17％。在白人青年中，3个BMI类别中的每个增加步骤的休闲收缩压均升高了约2 mmHg（健康体重为109.5 +/- 0.5 mmHg;有超重风险，为111.5 +/- 0.6 mmHg;超重，113.5 +/- 1.1 mmHg）。动态收缩压显示出与BMI升高相似的升高。在黑人青年中，观察到的动态夜间血压随BMI的绝对升高而下降。在两个种族组中，从健康体重到有超重到超重的风险，心输出量和中风量都得到显着提高。在黑人青年中，随BMI的增加，休闲和动态心率均显着增加。此外，从健康体重组到有超重危险的组，左心室质量指数呈线性增加，超重组的值最高。在白人青年中，随着BMI的增加，颈动脉-足背的脉搏波速度显着增加。无论种族如何，过夜钠排泄都显示出从健康体重受试者到超重受试者的显着增加，并且有超重受试者处于中间值的风险。结论：与健康体重的年轻人相比，有超重风险的年轻人似乎具有更高的心血管风险。我们的数据表明，超重危险状态已经在青少年中产生临床意义。

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