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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Impact of vaccination on the epidemiology of varicella: 1995-2009
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Impact of vaccination on the epidemiology of varicella: 1995-2009

机译:疫苗接种对水痘流行病学的影响:1995-2009年

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BACKGROUND: When varicella vaccine was licensed in the United States in 1995, there were concerns that childhood vaccination might increase the number of adolescents susceptible to varicella and shift disease toward older age groups where it can be more severe. METHODS: We conducted a series of 5 cross-sectional studies in 1994 to 1995 (prevaccine), 2000, 2003, 2006, and 2009 in Kaiser Permanente of Northern California to assess changes in varicella epidemiology in children and adolescents, as well as changes in varicella hospitalization in people of all ages. For each study, information on varicella history and varicella occurrence during the past year was obtained by telephone survey from a sample of ~8000 members 5 to 19 years old; varicella hospitalization rates were calculated for the entire membership. RESULTS: Between 1995 and 2009, the overall incidence of varicella in 5- to 19-year-olds decreased from 25.8 to 1.3 per 1000 person-years, a ~90% to 95% decline in the various age categories (5-9, 10-14, and 15-19 years of age). The proportion of varicella-susceptible children and adolescents also decreased in all age groups, including in 15- to 19-year-olds (from 15.6% in 1995 to 7.6% in 2009). From 1994 to 2009, age-adjusted varicella hospitalization rates in the general member population decreased from 2.13 to 0.25 per 100 000, a ~90% decline. CONCLUSIONS: In the 15 years after the introduction of varicella vaccine, a major reduction in varicella incidence and hospitalization was observed with no evidence of a shift in the burden of varicella to older age groups.
机译:背景:水痘疫苗于1995年在美国获得许可时,人们担心,儿童疫苗接种可能会增加易患水痘的青少年人数,并使疾病向更严重的年龄段转移。方法:我们于1994年至1995年(疫苗接种前),2000年,2003年,2006年和2009年在北加州的Kaiser Permanente进行了一系列5项横断面研究,以评估儿童和青少年水痘流行病学的变化以及水痘住院治疗的所有年龄段的人。对于每项研究,通过电话调查从5至19岁的约8000名成员的样本中获得了过去一年水痘病史和水痘发生的信息。计算整个成员的水痘住院率。结果:在1995年至2009年之间,五岁至19岁水痘的总发病率从每千人年25.8下降至1.3,在各个年龄段中均下降了约90%至95%(5-9, 10-14岁和15-19岁)。在所有年龄段,包括15至19岁的人群中,易患水痘的儿童和青少年的比例也有所下降(从1995年的15.6%降至2009年的7.6%)。从1994年到2009年,普通会员中按年龄调整的水痘住院率从2.13下降至0.25 / 100 000,下降了约90%。结论:在引入水痘疫苗后的15年中,水痘的发病率和住院率均大大降低,但没有证据表明水痘的负担已转移至老年人群。

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