Genome-Wide Association and Exome Sequencing Study of Language Disorder in an Isolated Population

Kornilov Sergey A.; Rakhlin Natalia; Koposov Roman; Lee Maria; Yrigollen Carolyn; Caglayan Ahmet Okay; Magnuson James S.; Mane Shrikant; Chang Joseph T.; Grigorenko Elena L.

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Genome-Wide Association and Exome Sequencing Study of Language Disorder in an Isolated Population

机译：人群中语言障碍的全基因组关联和外显子测序研究

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BACKGROUND AND OBJECTIVE: Developmental language disorder (DLD) is a highly prevalent neurodevelopmental disorder associated with negative outcomes in different domains; the etiology of DLD is unknown. To investigate the genetic underpinnings of DLD, we performed genome-wide association and whole exome sequencing studies in a geographically isolated population with a substantially elevated prevalence of the disorder (ie, the AZ sample).

机译：背景与目的：发育语言障碍（DLD）是一种高度流行的神经发育障碍，与不同领域的不良结果相关。 DLD的病因尚不清楚。为了调查DLD的遗传基础，我们在地理隔离的人群中进行了全基因组关联和整个外显子组测序研究，该人群的疾病患病率大大提高（即AZ样本）。

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《Pediatrics: Official Publication of the American Academy of Pediatrics》 |2016年第4期|共13页
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Kornilov Sergey A.; Rakhlin Natalia; Koposov Roman; Lee Maria; Yrigollen Carolyn; Caglayan Ahmet Okay; Magnuson James S.; Mane Shrikant; Chang Joseph T.; Grigorenko Elena L.;
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正文语种 eng
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1. Genome-Wide Association and Exome Sequencing Study of Language Disorder in an Isolated Population [J] . Kornilov Sergey A., Rakhlin Natalia, Koposov Roman, Pediatrics: Official Publication of the American Academy of Pediatrics . 2016,第4期

机译：人群中语言障碍的全基因组关联和外显子测序研究
2. Exome Sequencing in an Admixed Isolated Population Indicates NFXL1 Variants Confer a Risk for Specific Language Impairment [J] . Pía Villanueva, Ron Nudel, Alexander Hoischen, PLoS Genetics . 2015,第3期

机译：混合的孤立人群中的外显子组测序表明 NFXL1 变异会带来特定语言障碍的风险
3. Correction: Exome Sequencing in an Admixed Isolated Population IndicatesNFXL1 Variants Confer a Risk for Specific Language Impairment [J] . Pía Villanueva, Ron Nudel, Alexander Hoischen, PLoS Genetics . 2015,第6期

机译：更正：混合的孤立人群中的外显子组测序表明NFXL1变体带来特定语言障碍的风险
4. 4 Set-Based Gene × Environment Interaction Tests for Complex Diseases with Application to Genome-Wide Association and Sequencing Studies [C] . Shuo Jiao Symposium of the University of Georgia s Center for Contextual Genetics and Prevention Science . 2016

机译：基于4种基因×环境相互作用试验，复杂疾病应用于基因组 - 宽协会和测序研究
5. Using exome sequencing to study adaptive evolution in non-human primates and human populations. [D] . George, Renee D. 2012

机译：使用外显子组测序研究非人类灵长类动物和人类种群的适应性进化。
6. Genome-Wide Association and Exome Sequencing Study of Language Disorder in an Isolated Population [O] . Sergey A. Kornilov, Natalia Rakhlin, Roman Koposov, -1

机译：隔离人群语言障碍的全基因组关联和外显子组测序研究
7. Exome Sequencing in an Admixed Isolated Population Indicates NFXL1 Variants Confer a Risk for Specific Language Impairment [O] . Villanueva Pía, Nudel Ron, Hoischen Alexander, 2015

机译：混合隔离人群中的外显子组测序表明NFXL1变异赋予特定语言障碍的风险

Genome-Wide Association and Exome Sequencing Study of Language Disorder in an Isolated Population

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