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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Clinical trial of glucose-oral rehydration solution (ORS), rice dextrin-ORS, and rice flour-ORS for the management of children with acute diarrhea and mild or moderate dehydration.
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Clinical trial of glucose-oral rehydration solution (ORS), rice dextrin-ORS, and rice flour-ORS for the management of children with acute diarrhea and mild or moderate dehydration.

机译：葡萄糖-口服补液（ORS），大米糊精-ORS和大米粉-ORS的临床试验用于治疗急性腹泻和轻度或中度脱水的儿童。

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OBJECTIVE. To assess the effects of glucose (G)-oral rehydration solution (ORS), rice dextrin (RD)-ORS, and rice flour (RF)-ORS on fluid intake, rapidity of rehydration, and stool output of children with acute diarrhea and mild or moderate dehydration. METHODS. The study was a randomized, double-masked clinical trial. One hundred forty-six male infants, ages 3 to 36 months, were randomly assigned to one of three treatment groups. Clinical evaluations and fluid balances were conducted every 2 to 4 hours for 48 hours. Principal outcome variables were ORS consumption, recovery of hydration status, and fecal output. RESULTS. The groups were similar at admission with regard to age, nutritional status, history of the current episode, and clinical status. There were no differences in ORS consumption by treatment group during any period of study. During the first 6-hour period, patients in group RF had less stool output (16 +/- 14 g/kg/body weight) than those in group G (22 +/- 20 g/kg) or RD (21 +/- 19 g/kg; P < .05). After 12 hours of hospitalization, there were no differences by treatment group. Recovery of hydration status, changes in serum sodium and potassium, and duration of diarrhea in the hospital were similar in all three groups. CONCLUSION. There was a 24% to 27% reduction in stool output during the first 6 hours of treatment among children who received RF-ORS compared with those who received G-ORS or RD-ORS, but this effect did not persist after the first 12 hours of therapy. Because this difference was of small magnitude and limited duration, it has minor clinical importance. Thus, we conclude that the three solutions had similar efficacy for children with acute, watery diarrhea and mild or moderate dehydration.
机译：目的。评估葡萄糖（G）-口服补液（ORS），大米糊精（RD）-ORS和大米粉（RF）-ORS对急性腹泻儿童的液体摄入，补液速度和排便量的影响轻度或中度脱水。方法。该研究是一项随机，双重掩盖的临床试验。年龄为3至36个月的146名男婴被随机分配到三个治疗组之一。每2至4小时进行临床评估和体液平衡，持续48小时。主要结果变量为ORS消耗，水合状态恢复和粪便排出量。结果。入院时的年龄，营养状况，当前发作史和临床状况相似。在任何研究期间，各治疗组的ORS消耗量均无差异。在最初的6小时内，RF组的粪便输出量（16 +/- 14 g / kg /体重）比G组（22 +/- 20 g / kg）或RD（21 + / -19 g / kg; P <.05）。住院12小时后，各治疗组无差异。三组患者的水化状态恢复，血清钠和钾的变化以及腹泻的持续时间相似。结论。与接受G-ORS或RD-ORS的儿童相比，接受RF-ORS的儿童在治疗的前6个小时的粪便输出减少了24％至27％，但这种效果在最初的12个小时后并没有持续治疗。由于这种差异的幅度小且持续时间有限，因此其临床意义不大。因此，我们得出结论，这三种解决方案对急性，水样腹泻和轻度或中度脱水的儿童具有相似的疗效。

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