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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Renal and absorptive hypercalciuria: a metabolic disturbance with varying and interchanging modes of expression.
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Renal and absorptive hypercalciuria: a metabolic disturbance with varying and interchanging modes of expression.

机译：肾和吸收性高钙尿症：一种具有变化和互换表达方式的代谢紊乱。

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BACKGROUND: In previous studies, the oral calcium loading and deprivation test has been used to distinguish between children with renal (fasting) hypercalciuria (RH) and absorptive hypercalciuria (AH). OBJECTIVE: We evaluated the long-term clinical course of 30 children with idiopathic hypercalciuria and investigated the influence of urinary sodium excretion, as a reflection of its intake, on urinary calcium excretion. METHODS: Thirty normocalcemic, normophosphatemic children (21 boys and 9 girls) with urinary calcium to creatinine ratios greater than 0.57 mmol/L/mmol/L ( > 0.21 mg/dL/mg/dL on the three consecutive examinations participated in this study. They were divided according to their responses to calcium deprivation and loading into AH (16 patients) and RH (14 patients). RESULTS: When restudied 3 to 7 years later, 6 of the 16 children with AH were normocalciuric and three demonstrated characteristics compatible with RH. The remaining seven patients maintained their initial AH pattern. Of the 14children with RH, four were normocalciuric and four demonstrated AH. The remaining six children maintained their initial RH pattern. A significant positive correlation was observed between urine sodium and calcium excretion in children with AH or RH. Children who were normocalciuric at the second study had significantly lower values of urine sodium excretion when compared with those in whom hypercalciuria persisted. CONCLUSIONS: We suggest that AH and RH constitute a continuum. The change in characteristics observed during the second study suggests that any attempt to divide these patients into two physiologically distinct subtypes may be artificial. The main factor influencing urinary excretion of calcium in our patients seemed to be sodium intake.
机译：背景：在先前的研究中，口服钙负荷和剥夺测试已被用于区分肾（禁食）高钙尿症（RH）和吸收性高钙尿症（AH）的儿童。目的：我们评估了30例特发性高钙尿症患儿的长期临床病程，并调查了尿钠排泄（反映其摄入量）对尿钙排泄的影响。方法：30名正常钙血，正常磷酸盐血症的儿童（21名男孩和9名女孩）尿钙与肌酐之比大于0.57 mmol / L / mmol / L（在连续三项检查中均> 0.21 mg / dL / mg / dL）参加了这项研究。结果：根据他们对钙缺乏和钙负荷的反应分为AH（16例）和RH（14例）结果：在3至7年后进行研究时，在16例AH儿童中，有6例为正常尿钙尿酸，其中3例表现出与正常人相适应的特征。 RH。其余7例患者保持其最初的AH模式;在14例RH儿童中，有4例为正常钙尿，4例显示为AH。其余6例儿童保持了其初始RH模式。患有AH或RH的儿童在第二项研究中血钙正常的儿童与尿钙过多的儿童相比，其尿钠排泄值明显较低我一直坚持。结论：我们建议AH和RH构成一个连续体。在第二项研究中观察到的特征变化表明，将这些患者分为两种生理上不同的亚型的任何尝试都是人工的。影响我们患者尿钙排泄的主要因素似乎是钠的摄入量。

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