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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Case Report: Rapidly Healing Epidermolysis Bullosa Wound After Ablative Fractional Resurfacing
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Case Report: Rapidly Healing Epidermolysis Bullosa Wound After Ablative Fractional Resurfacing

机译：病例报告：消融性表面重铺后迅速治愈大疱性表皮松解伤

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摘要

Recessive dystrophic epidermolysis bullosa (RDEB) is a devastating genodermatosis characterized by generalized skin fragility, severe blistering, and wounding that heals with mutilating scarring. Patients are in constant need of effective wound therapies as they often succumb to aggressive metastatic squamous cell carcinomas or to sepsis that may develop from their chronic wounds. Herein, we demonstrate accelerated wound healing with use of a fractionated CO2 laser protocol in a 22-year-old man with RDEB. His 9-month-old, non-healing wound decreased from 7 cm in diameter to 2 cm in diameter (a 92% reduction in wound surface area) within 4 weeks of a single laser treatment, and he had near-complete re-epithelialization within 4 weeks of his second laser treatment without blistering or other adverse effects. This novel intervention of using fractionated CO2 for photo-microdebridement could help revolutionize wound care for patients who have RDEB and whose chronic wounds serve as one of their greatest sources of morbidity and mortality. Dissemination to a pediatric audience is critical so that laser protocols might be more thoroughly investigated and incorporated into wound management strategies for this uniquely vulnerable population.
机译：隐性营养不良性大疱性表皮松解症（RDEB）是一种破坏性的皮肤病，其特征是皮肤普遍脆弱，严重水疱和伤口愈合，并造成残缺的疤痕。患者不断需要有效的伤口疗法，因为他们经常屈服于侵袭性转移性鳞状细胞癌或可能因其慢性伤口发展而引起的败血症。在本文中，我们证明了在22岁的RDEB男性中使用分级CO2激光方案可加速伤口愈合。在一次激光治疗后的4周内，他的9个月大，无法愈合的伤口从直径7厘米减小到了2厘米（伤口表面积减少了92％），并且他的上皮再生几乎完全在第二次激光治疗后的4周内没有起泡或其他不良影响。使用分馏的CO2进行光微清创术的这种新颖干预措施可以帮助彻底改变针对RDEB且慢性伤口是其最大发病率和死亡率来源之一的患者的伤口护理。向小儿听众传播至关重要，因此可以对激光协议进行更彻底的调查，并将其纳入针对这一独特脆弱人群的伤口处理策略中。

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